Further evidence of altered redox status of hyperbilirubinaemic patients: Role of bilirubin in Gilbert syndrome

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9 Citations (Scopus)

Abstract

Bilirubin is regarded as the most powerful endogenous antioxidant substance. It exhibits immunmodulator, inhibitor activities on kinases, yet it is clear that it can be potentially cytotoxic. Gilbert syndrome is characterised by hereditary, chronic, mild unconjugated hyperbilirubinaemia. 12 Gilbert syndrome patients and 15 healthy controls were investigated with special regard to reduction-oxidation status and free radical-antioxidant balance. Sera free SH-group concentration, H-donating ability, reducing power were measured spectrophotometric methods. Total scavenger capacity, describing free radical-antioxidant balance, was determined by a newly developed chemiluminometric method in sera, plasma and erythrocytes. Patients with Gilbert syndrome showed a significant increase of non-enzymatic antioxidant capacity. Elevated free SH-group concentration, H-donating ability and reducing power were found in mild hyperbilirubinaemia compared with control group patients. On the other hand no significant differences were detected regarding free radical-antioxidant balance in sera, plasma and erythrocytes between the groups. On the basis of these results it can be supposed that elevated bilirubin concentration, via indirect or compensatory way, strengthens non-enzymatic antioxidant capacity, without changes in antioxidant-free radical balance. That is why further investigations are needed to clarify the consequences of elevated bilirubin concentration on cell redox homeostasis.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalActa Biologica Szegediensis
Volume47
Issue number1-4
Publication statusPublished - Dec 1 2003

Keywords

  • Free radical-antioxidant balance
  • Gilbert syndrome
  • Redox status
  • Total scavenger capacity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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