Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families

Sibylle G. Schwab, Barbara Hoefgen, Claudia Hanses, Margitta Borrmann Hassenbach, Margot Albus, Bernard Lerer, M. Trixler, Wolfgang Maier, Dieter B. Wildenauer

Research output: Contribution to journalArticle

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Abstract

Background: Involvement of AKT signaling pathways in schizophrenia has been recently suggested, on the basis of several lines of evidence. In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample. Methods: We investigated the reported association of DNA sequence variants in the AKT1 gene in a sample of 79 sib-pair families with schizophrenia using the five single nucleotide polymorphisms (SNPs) of the original study and two additional SNPs in the neighborhood of the SNP for which association had been reported. Results: We obtained statistical significance for single markers (p = .002) and multilocus haplotypes (p = .0013) located in the same region as has been reported in the previous study. Conclusions: The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalBiological Psychiatry
Volume58
Issue number6
DOIs
Publication statusPublished - Sep 15 2005

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Schizophrenia
Single Nucleotide Polymorphism
Genes
Haplotypes
Phosphorylation
Proteins

Keywords

  • AKT1
  • family based analysis
  • haplotypes
  • replication of association
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Schwab, S. G., Hoefgen, B., Hanses, C., Hassenbach, M. B., Albus, M., Lerer, B., ... Wildenauer, D. B. (2005). Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families. Biological Psychiatry, 58(6), 446-450. https://doi.org/10.1016/j.biopsych.2005.05.005

Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families. / Schwab, Sibylle G.; Hoefgen, Barbara; Hanses, Claudia; Hassenbach, Margitta Borrmann; Albus, Margot; Lerer, Bernard; Trixler, M.; Maier, Wolfgang; Wildenauer, Dieter B.

In: Biological Psychiatry, Vol. 58, No. 6, 15.09.2005, p. 446-450.

Research output: Contribution to journalArticle

Schwab, SG, Hoefgen, B, Hanses, C, Hassenbach, MB, Albus, M, Lerer, B, Trixler, M, Maier, W & Wildenauer, DB 2005, 'Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families', Biological Psychiatry, vol. 58, no. 6, pp. 446-450. https://doi.org/10.1016/j.biopsych.2005.05.005
Schwab, Sibylle G. ; Hoefgen, Barbara ; Hanses, Claudia ; Hassenbach, Margitta Borrmann ; Albus, Margot ; Lerer, Bernard ; Trixler, M. ; Maier, Wolfgang ; Wildenauer, Dieter B. / Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families. In: Biological Psychiatry. 2005 ; Vol. 58, No. 6. pp. 446-450.
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