Fungicidal activity of azole antifungal agents

L. Majoros, G. Kardos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Treatment of invasive fungal infections with fungicidal antifungal agents is desirable in some clinical situations, particularly in the immunocompromised. However, there are a limited number of fungicidal dnigs and most have undesirable side effects. Applicability of amphotericin B and its different lipid formulations is hampered by toxicity and the relatively low attainable serum concentration (not more than 1 μg/ml). Echinocandin antifungals (caspofungin, micafungin and anidulafungin) have a relatively narrow spectrum (Candida and some Aspergillus species), moreover, they are fungistatic against Aspergillus. The newer triazoles (voriconazole and posaconazole) offer broad spectrum of activity against pathogenic yeasts and moulds. Several recent studies described species dependent fungicidal activity of both voriconazole and posaconazole in vitro. These results are supported by results from animal models. This fungicidal activity has been thought to be confined to moulds only, but recent in vitro findings suggest that they exert fungicidal action against certain yeast species as well. Present work focuses on the Bangistatic and fungicidal effect of azole antifungals against yeast and moulds, concentrating in particular on voriconale and posaconazole.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalAnti-Infective Agents in Medicinal Chemistry
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

Keywords

  • Animal models
  • Fungicidal action
  • Minimal fungicidal concentration
  • Time-kill method
  • Triazoles

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases

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