Az állófázis-optimalizált szelektivitá sú folyadékkromatográfia (SOS-LC) alapjai: "Olyan ember számára, aki szellemi életet él, nincs halál." (Tolsztoj)

Translated title of the contribution: Fundamentals of stationary phase optimized selectivity LC (SOS-LC)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A new procedure (SOS-LC) is described for the optimization of the HPLC stationary phase, using serially connected columns and the principle of the "PRISMA" model. In the course of the base measurements the retention factors (k) of the analytes were determined on three different base stationary phases; other parameters were fixed. By use of these data the k values were predicted in the cases of all theoretically combined stationary phases. These predictions resulted in numerous intermediate theoretical separations but only the optimal one was compiled and tested applying other parameters fixed as in the case of the base measurements. The overall selectivity of this separation was better than that of any individual stationary phase. SOS-LC is independent of the mechanism and the scale of separation and will be very advantageous in the case of hyphenated techniques (LC-MS and LC-NMR) due to stable mobile phase background.

Translated title of the contributionFundamentals of stationary phase optimized selectivity LC (SOS-LC)
Original languageHungarian
Pages (from-to)65-71
Number of pages7
JournalActa pharmaceutica Hungarica
Volume77
Issue number1
Publication statusPublished - Jan 1 2007

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Fundamentals of stationary phase optimized selectivity LC (SOS-LC): "Olyan ember számára, aki szellemi életet él, nincs halál." (Tolsztoj)'. Together they form a unique fingerprint.

  • Cite this