Functionally and structurally relevant residues of enzymes: Are they segregated or overlapping?

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7 Citations (Scopus)


There is a delicate balance between stability and flexibility needed for enzyme function. To avoid undesirable alteration of the functional properties during the evolutionary optimization of the structural stability under certain circumstances, and vice versa, to avoid unwanted changes of stability during the optimization of the functional properties of proteins, common sense would suggest that parts of the protein structure responsible for stability and parts responsible for function developed and evolved separately. This study shows that nature did not follow this anthropomorphic logic: the set of residues involved in function and those involved in structural stabilization of enzymes are rather overlapping than segregated.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalFEBS letters
Issue number2-3
Publication statusPublished - Jun 4 2004


  • Binding sites
  • Catalytic sites
  • EC, enzyme commission
  • OFSR, overlapping functional-structural residue
  • PDB, protein data bank
  • SC, stabilization center
  • Stabilization center
  • Statistical analysis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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