Functionalized mesoporous silica nanoparticles for oral delivery of budesonide

K. Yoncheva, M. Popova, A. Szegedi, J. Mihály, B. Tzankov, N. Lambov, S. Konstantinov, V. Tzankova, F. Pessina, M. Valoti

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Non-functionalized and amino-functionalized mesoporous silica nanoparticle were loaded with anti-inflammatory drug budesonide and additionally post-coated with bioadhesive polymer (carbopol). TEM images showed spherical shape of the nanoparticles and slightly higher polydispersity after coating with carbopol. Nitrogen physisorption and thermogravimetic analysis revealed that more efficient loading and incorporation into the pores of nanoparticles was achieved with the amino-functionalized silica carrier. Infrared spectra indicated that the post-coating of these nanoparticles with carbopol led to the formation of bond between amino groups of the functionalized carrier and carboxyl groups of carbopol. The combination of amino-functionalization of the carrier with the post-coating of the nanoparticles sustained budesonide release. Further, an in vitro model of inflammatory bowel disease showed that the cytoprotective effect of budesonide loaded in the post-coated silica nanoparticles on damaged HT-29 cells was more pronounced compared to the cytoprotection obtained with pure budesonide.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalJournal of Solid State Chemistry
Volume211
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Budesonide
Silicon Dioxide
delivery
Silica
Nanoparticles
silicon dioxide
nanoparticles
Coatings
coatings
Physisorption
carboxyl group
Polydispersity
coating
Polymers
drugs
Anti-Inflammatory Agents
Nitrogen
infrared spectra
Transmission electron microscopy
Infrared radiation

Keywords

  • Budesonide release
  • Carbopol coating
  • Cytoprotective effect
  • Mesoporous silica nanoparticles

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

Cite this

Functionalized mesoporous silica nanoparticles for oral delivery of budesonide. / Yoncheva, K.; Popova, M.; Szegedi, A.; Mihály, J.; Tzankov, B.; Lambov, N.; Konstantinov, S.; Tzankova, V.; Pessina, F.; Valoti, M.

In: Journal of Solid State Chemistry, Vol. 211, 03.2014, p. 154-161.

Research output: Contribution to journalArticle

Yoncheva, K, Popova, M, Szegedi, A, Mihály, J, Tzankov, B, Lambov, N, Konstantinov, S, Tzankova, V, Pessina, F & Valoti, M 2014, 'Functionalized mesoporous silica nanoparticles for oral delivery of budesonide', Journal of Solid State Chemistry, vol. 211, pp. 154-161. https://doi.org/10.1016/j.jssc.2013.12.020
Yoncheva, K. ; Popova, M. ; Szegedi, A. ; Mihály, J. ; Tzankov, B. ; Lambov, N. ; Konstantinov, S. ; Tzankova, V. ; Pessina, F. ; Valoti, M. / Functionalized mesoporous silica nanoparticles for oral delivery of budesonide. In: Journal of Solid State Chemistry. 2014 ; Vol. 211. pp. 154-161.
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