Functional variants of the interleukin-23 receptor gene in non-gastrointestinal autoimmune diseases

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23 Citations (Scopus)

Abstract

Variants of the gene of the interleukin-23 receptor (IL23R) were first identified as susceptibility factors in association with inflammatory bowel diseases. Since then it became clear that different variants of the gene play role also in a number of other autoimmune diseases like psoriasis, rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis while in others, like systemic sclerosis, systemic lupus erythematosus or Sjögren syndrome the same effect could not be seen. However, the results are very controversial both in terms of the various polymorphisms and also in population specificity. The aim of the current paper is to overview all available reports on IL23R gene polymorphisms in various autoimmune and inflammatory diseases and to try to give an explanation on the possible effect of the examined variants.

Original languageEnglish
Pages (from-to)3766-3774
Number of pages9
JournalCurrent Medicinal Chemistry
Volume16
Issue number28
DOIs
Publication statusPublished - 2009

Fingerprint

Interleukin Receptors
Interleukin-23
Autoimmune Diseases
Genes
Polymorphism
Systemic Scleroderma
Ankylosing Spondylitis
Inflammatory Bowel Diseases
Psoriasis
Systemic Lupus Erythematosus
Multiple Sclerosis
Rheumatoid Arthritis
Population

Keywords

  • Autoimmune
  • IL23R
  • Interleukin-23
  • Polymorphism

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

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abstract = "Variants of the gene of the interleukin-23 receptor (IL23R) were first identified as susceptibility factors in association with inflammatory bowel diseases. Since then it became clear that different variants of the gene play role also in a number of other autoimmune diseases like psoriasis, rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis while in others, like systemic sclerosis, systemic lupus erythematosus or Sj{\"o}gren syndrome the same effect could not be seen. However, the results are very controversial both in terms of the various polymorphisms and also in population specificity. The aim of the current paper is to overview all available reports on IL23R gene polymorphisms in various autoimmune and inflammatory diseases and to try to give an explanation on the possible effect of the examined variants.",
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