Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis

B. Faragó, L. Magyari, E. Sáfrány, V. Csöngei, L. Járomi, K. Horvatovich, C. Sipeky, A. Maász, J. Radics, Á Gyetvai, Z. Szekanecz, L. Czirják, B. Melegh

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Abstract

Objectives: Recently, an association was found between Crohn's disease and the interleukin-23 receptor (IL-23R) gene. Since the IL-23/IL-17 pathway is known to associate with other autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc), we hypothesised that IL-23R could be a shared susceptibility gene. Methods: Groups of patients with rheumatoid arthritis (n = 412), systemic sclerosis (n = 224), Crohn's disease (n = 190) and healthy controls (n = 220) were genotyped for rs10889677 (exon-3′UTR C2370A), rs2201841, and rs 1884444 variants; the first two have been shown to confer risk for Crohn's disease. Results: We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%. p2 = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and χ2 = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841). The rs1884444 allele, which has been previously reported as neutral for development of Crohn's disease, was also found neutral for all studied groups in the present study. Conclusions: The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Interleukin Receptors
Interleukin-23
Systemic Scleroderma
Crohn Disease
Rheumatoid Arthritis
Genes
Interleukin-17
Rheumatoid Factor
Autoimmune Diseases
Exons
Alleles
Genotype

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

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title = "Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis",
abstract = "Objectives: Recently, an association was found between Crohn's disease and the interleukin-23 receptor (IL-23R) gene. Since the IL-23/IL-17 pathway is known to associate with other autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc), we hypothesised that IL-23R could be a shared susceptibility gene. Methods: Groups of patients with rheumatoid arthritis (n = 412), systemic sclerosis (n = 224), Crohn's disease (n = 190) and healthy controls (n = 220) were genotyped for rs10889677 (exon-3′UTR C2370A), rs2201841, and rs 1884444 variants; the first two have been shown to confer risk for Crohn's disease. Results: We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1{\%}, 11.9{\%} vs 5.91{\%}. p2 = 5.58, p = 0.018, OR = 2.15, 95{\%} CI 1.14-4.06 for rs10889677; and χ2 = 7.45, p = 0.006, OR = 2.40, 95{\%} CI 1.28-4.51 for rs2201841). The rs1884444 allele, which has been previously reported as neutral for development of Crohn's disease, was also found neutral for all studied groups in the present study. Conclusions: The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.",
author = "B. Farag{\'o} and L. Magyari and E. S{\'a}fr{\'a}ny and V. Cs{\"o}ngei and L. J{\'a}romi and K. Horvatovich and C. Sipeky and A. Ma{\'a}sz and J. Radics and {\'A} Gyetvai and Z. Szekanecz and L. Czirj{\'a}k and B. Melegh",
year = "2008",
month = "2",
doi = "10.1136/ard.2007.072819",
language = "English",
volume = "67",
pages = "248--250",
journal = "Annals of the Rheumatic Diseases",
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TY - JOUR

T1 - Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis

AU - Faragó, B.

AU - Magyari, L.

AU - Sáfrány, E.

AU - Csöngei, V.

AU - Járomi, L.

AU - Horvatovich, K.

AU - Sipeky, C.

AU - Maász, A.

AU - Radics, J.

AU - Gyetvai, Á

AU - Szekanecz, Z.

AU - Czirják, L.

AU - Melegh, B.

PY - 2008/2

Y1 - 2008/2

N2 - Objectives: Recently, an association was found between Crohn's disease and the interleukin-23 receptor (IL-23R) gene. Since the IL-23/IL-17 pathway is known to associate with other autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc), we hypothesised that IL-23R could be a shared susceptibility gene. Methods: Groups of patients with rheumatoid arthritis (n = 412), systemic sclerosis (n = 224), Crohn's disease (n = 190) and healthy controls (n = 220) were genotyped for rs10889677 (exon-3′UTR C2370A), rs2201841, and rs 1884444 variants; the first two have been shown to confer risk for Crohn's disease. Results: We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%. p2 = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and χ2 = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841). The rs1884444 allele, which has been previously reported as neutral for development of Crohn's disease, was also found neutral for all studied groups in the present study. Conclusions: The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.

AB - Objectives: Recently, an association was found between Crohn's disease and the interleukin-23 receptor (IL-23R) gene. Since the IL-23/IL-17 pathway is known to associate with other autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc), we hypothesised that IL-23R could be a shared susceptibility gene. Methods: Groups of patients with rheumatoid arthritis (n = 412), systemic sclerosis (n = 224), Crohn's disease (n = 190) and healthy controls (n = 220) were genotyped for rs10889677 (exon-3′UTR C2370A), rs2201841, and rs 1884444 variants; the first two have been shown to confer risk for Crohn's disease. Results: We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%. p2 = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and χ2 = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841). The rs1884444 allele, which has been previously reported as neutral for development of Crohn's disease, was also found neutral for all studied groups in the present study. Conclusions: The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.

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U2 - 10.1136/ard.2007.072819

DO - 10.1136/ard.2007.072819

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C2 - 17606463

AN - SCOPUS:38749138182

VL - 67

SP - 248

EP - 250

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

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