Functional significance of genetic abnormalities in multiple myeloma

Klara Gadó, Gyula Domján, Luca Kormos, András Falus

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Multiple myeloma (MM) is a B-cell neoplasm characterized by infiltration of the bone marrow with malignant plasma cells, synthesizing and secreting monoclonal immunoglobulin fragments. The malignant transformation of this terminally differentiated plasma cell is the result of a multistep transformation process. In spite of recent advances in this field, the cause and the exact molecular genetic basis of MM remain obscure. In this review, an attempt has been made to summarize the genetic alterations having functional significance in the generation and progression of MM, and also the existing relationship between genetic abnormalities and chemosensitivity, as well as the typical genetic alterations in various MM subgroups. Factors known to have a role in the conversion of monoclonal gammopathy of unknown significance (MGUS) to MM are also reviewed.

Original languageEnglish
Pages (from-to)191-208
Number of pages18
JournalHaematologia
Volume32
Issue number3
DOIs
Publication statusPublished - Dec 1 2002

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Keywords

  • Chromosomal abnormalities
  • Genetic alterations
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology

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