Functional neurotoxicity of Mn-containing nanoparticles in rats

Gábor Oszlánczi, Tünde Vezér, Leila Sárközi, Endre Horváth, Z. Kónya, A. Papp

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Airborne metal-containing particles represent a known source of health risk but the role of nano-sized particles in the pathogenicity of dust has been recognized only recently. As a model of inhalational exposure to manganese, adult male Wistar rats were treated with a suspension of MnO2 nanoparticles of ca23nm diameter, instilled into the trachea for 3, 6, and 9 weeks in daily doses of 2.63 and 5.26mg Mn/kg, and endpoints of functional neurotoxicity (open field behavior and electrophysiology) and general toxicity (body and organ weights) were investigated. Weekly body weighing showed that control rats had normal weight gain but the treated rats' body weight failed to increase from the 6th week on. Dissection and organ weighing after the corresponding treatment periods revealed dose- and time-dependently increased relative lung weights. In brain and blood samples, significantly elevated Mn level was detected after 9 weeks exposure. The treated rats' open field behavior showed decreased ambulation and rearing, and increased local activity and immobility. Electrophysiological investigations after 9 weeks exposure indicated a shift of the spontaneous cortical activity to higher frequencies, lengthened cortical evoked potential latency, and slowed nerve conduction. Several of these general and neuro-functional parameters were significantly correlated to the tissue Mn levels. Instilled Mn in nanoparticle form was indeed absorbed and exerted neurotoxic effects, so the model seems suitable for studying the effects of airborne nanoparticles, relevant to human health.

Original languageEnglish
Pages (from-to)2004-2009
Number of pages6
JournalEcotoxicology and Environmental Safety
Volume73
Issue number8
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Nanoparticles
Rats
Weighing
Body Weight
Rat control
Electrophysiology
Dissection
Organ Size
Health risks
Neural Conduction
Bioelectric potentials
Health
Manganese
Trachea
Dust
Evoked Potentials
Particles (particulate matter)
Weight Gain
Walking
Toxicity

Keywords

  • Behavior
  • Deposition
  • Electrophysiology
  • Intratracheal instillation
  • Manganese
  • Nanoparticle

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pollution

Cite this

Functional neurotoxicity of Mn-containing nanoparticles in rats. / Oszlánczi, Gábor; Vezér, Tünde; Sárközi, Leila; Horváth, Endre; Kónya, Z.; Papp, A.

In: Ecotoxicology and Environmental Safety, Vol. 73, No. 8, 11.2010, p. 2004-2009.

Research output: Contribution to journalArticle

Oszlánczi, Gábor ; Vezér, Tünde ; Sárközi, Leila ; Horváth, Endre ; Kónya, Z. ; Papp, A. / Functional neurotoxicity of Mn-containing nanoparticles in rats. In: Ecotoxicology and Environmental Safety. 2010 ; Vol. 73, No. 8. pp. 2004-2009.
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