Functional neurotoxic effects in rats acutely exposed to insecticide combinations

Zsuzsanna Lengyel, A. Szabó, A. Papp, L. Nagymajtényi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the present study was to analyse the alterations in the cortical and peripheral electrophysiological activity of rats acutely treated with combinations of insecticides. Young adult male Wistar rats were treated with 1/5 and 1/25 LD50 of the insecticides dimethoate, propoxur, cypermethrin and amitraz, given alone or in triple or quadruple combinations. After 24 h, spontaneous cortical activity, and stimulus-evoked cortical and peripheral responses, was recorded and analysed. All treatments changed the cortical activity spectrum. The effect of the 1/5 LD50 combinations indicated non-additive interactions. In the cortical-evoked responses, dimethoate and its combinations gave the strongest change in the latency, while amitraz and its combinations, in the response duration. In the tail nerve, relative refractory period was the most sensitive parameter. The frequency dependence of the cortical responses was the most strongly altered by propoxur, and the least, by amitraz. Our results indicate that simultaneous exposure by various pesticide agents, which happens possibly also in humans, deserves further investigation in, among others, neurotoxicological points of view.

Original languageEnglish
Pages (from-to)94-102
Number of pages9
JournalPesticide Biochemistry and Physiology
Volume87
Issue number1
DOIs
Publication statusPublished - Jan 2007

Fingerprint

amitraz
Propoxur
Insecticides
Dimethoate
propoxur
Rats
dimethoate
insecticides
Lethal Dose 50
lethal dose 50
rats
cypermethrin
young adults
Pesticides
Refractory materials
Tail
Wistar Rats
Young Adult
nerve tissue
tail

Keywords

  • Combined exposure
  • Cortical activity
  • Insecticides
  • Neurotoxicity
  • Peripheral activity
  • Rat

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Biochemistry
  • Physiology

Cite this

Functional neurotoxic effects in rats acutely exposed to insecticide combinations. / Lengyel, Zsuzsanna; Szabó, A.; Papp, A.; Nagymajtényi, L.

In: Pesticide Biochemistry and Physiology, Vol. 87, No. 1, 01.2007, p. 94-102.

Research output: Contribution to journalArticle

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