Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery

J. Janszky, Hennric Jokeit, Konstantina Kontopoulou, Markus Mertens, Alois Ebner, Bernd Pohlmann-Eden, Friedrich G. Woermann

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Purpose: Anterior temporal lobe resection (ATR) is a treatment option in drug-resistant epilepsy. An important risk of ATR is loss of memory because mesiotemporal structures contribute substantially to memory function. We investigated whether memory-activated functional MRI (fMRI) can predict postoperative memory loss after anterior temporal lobectomy in right-sided medial temporal lobe epilepsy (MTLE). Methods: We included 16 patients (10 women) aged 16-54 years. The mean age at epilepsy onset was 12.5 years (range, 1-26 years). The patients' mean Wechsler IQ score was 95.2 (range, 62-125). The activation condition of fMRI consisted of retrieval from long-term memory induced by self-paced performance of an imaginative walk. All but one patient had left-sided speech dominance according to speech-activated fMRI. Outside the scanner, we evaluated the pre- and postoperative visual memory retention by using Rey Visual Design Learning Test. Results: We found a correlation between the preoperative asymmetry index of memory-fMRI and the change between pre-and postsurgical measures of memory retention. Reduced activation of the mesiotemporal region ipsilateral to the epileptogenic region correlated with a favorable memory outcome after right-sided ATR. Conclusions: In light of the postoperative results, the theoretical implication of our study is that fMRI based on a simple introspective retrieval task measures memory functions. The main clinical implication of our study is that memory-fMRI might replace the invasive Wada test in MTLE by using a simple fMRI paradigm. Predictive power, however, will be studied in larger patient samples. Other studies are required for left-sided MTLE and neocortical epilepsies to assess the clinical usefulness of memory-fMRI.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalEpilepsia
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2005

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Epilepsy
Magnetic Resonance Imaging
Temporal Lobe Epilepsy
Temporal Lobe
Memory Disorders
Anterior Temporal Lobectomy
Long-Term Memory
Age of Onset
Learning

Keywords

  • Epilepsy surgery
  • Fmri
  • Postoperative memory loss
  • Right-sided temporal lobe epilepsy
  • Visuospatial memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Janszky, J., Jokeit, H., Kontopoulou, K., Mertens, M., Ebner, A., Pohlmann-Eden, B., & Woermann, F. G. (2005). Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery. Epilepsia, 46(2), 244-250. https://doi.org/10.1111/j.0013-9580.2005.10804.x

Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery. / Janszky, J.; Jokeit, Hennric; Kontopoulou, Konstantina; Mertens, Markus; Ebner, Alois; Pohlmann-Eden, Bernd; Woermann, Friedrich G.

In: Epilepsia, Vol. 46, No. 2, 02.2005, p. 244-250.

Research output: Contribution to journalArticle

Janszky, J, Jokeit, H, Kontopoulou, K, Mertens, M, Ebner, A, Pohlmann-Eden, B & Woermann, FG 2005, 'Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery', Epilepsia, vol. 46, no. 2, pp. 244-250. https://doi.org/10.1111/j.0013-9580.2005.10804.x
Janszky, J. ; Jokeit, Hennric ; Kontopoulou, Konstantina ; Mertens, Markus ; Ebner, Alois ; Pohlmann-Eden, Bernd ; Woermann, Friedrich G. / Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery. In: Epilepsia. 2005 ; Vol. 46, No. 2. pp. 244-250.
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