Functional molecular biology of the TRPV1 ion channel

I. Nagy, John P M White, Cleoper C. Paule, Mervyn Maze, Laszlo Urban

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

This chapter offers an introduction to the structure and function of TRPV1 receptor. In terms of activators and sites of interaction, we elaborate at least five mechanisms by which TRPV1 receptor may be activated, including ligand binding, protonation, post-translational changes, thermal energy, and electrical energy. The sub-cellular expression of TRPV1 receptor and its expression in primary sensory neurons in the central nervous system and by non-neuronal cells are also examined, as is co-expression of TRPV1 receptor with the cannabinoid 1 receptor. The cellular responses to TRPV1 receptor activation are discussed, including its role in generating ionic influx into primary sensory neurons and desensitisation of TRPV1 receptor. Finally, consideration is afforded to the role of TRPV1 receptor in physiological and pathological conditions.

Original languageEnglish
Title of host publicationCannabinoids and the Brain
PublisherSpringer US
Pages101-130
Number of pages30
ISBN (Print)9780387743493, 9780387743486
DOIs
Publication statusPublished - 2008

Fingerprint

Ion Channels
Molecular Biology
Sensory Receptor Cells
Cannabinoid Receptors
TRPV1 receptor
Central Nervous System
Hot Temperature
Ligands

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Nagy, I., White, J. P. M., Paule, C. C., Maze, M., & Urban, L. (2008). Functional molecular biology of the TRPV1 ion channel. In Cannabinoids and the Brain (pp. 101-130). Springer US. https://doi.org/10.1007/978-0-387-74349-3_8

Functional molecular biology of the TRPV1 ion channel. / Nagy, I.; White, John P M; Paule, Cleoper C.; Maze, Mervyn; Urban, Laszlo.

Cannabinoids and the Brain. Springer US, 2008. p. 101-130.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nagy, I, White, JPM, Paule, CC, Maze, M & Urban, L 2008, Functional molecular biology of the TRPV1 ion channel. in Cannabinoids and the Brain. Springer US, pp. 101-130. https://doi.org/10.1007/978-0-387-74349-3_8
Nagy I, White JPM, Paule CC, Maze M, Urban L. Functional molecular biology of the TRPV1 ion channel. In Cannabinoids and the Brain. Springer US. 2008. p. 101-130 https://doi.org/10.1007/978-0-387-74349-3_8
Nagy, I. ; White, John P M ; Paule, Cleoper C. ; Maze, Mervyn ; Urban, Laszlo. / Functional molecular biology of the TRPV1 ion channel. Cannabinoids and the Brain. Springer US, 2008. pp. 101-130
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