Functional models of nonheme diiron enzymes: Kinetic and computational evidence for the formation of oxoiron(IV) species from peroxo-diiron(III) complexes, and their reactIVity towards phenols and H2O2

Miklós István Szávuly, Mihai Surducan, Emoke Nagy, Mátyás Surányi, G. Speier, Radu Silaghi-Dumitrescu, J. Kaizer

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Abstract

The reactivity of the previously reported peroxo adducts [Fe2(μ-O2)(L1)4(CH3CN)2]2+, and [Fe2(μ-O2)(L2)4(CH3CN)2]2+, (L1 = 2-(2′-pyridyl)benzimidazole and L2 = 2-(2′-pyridyl)-N-methylbenzimidazole) towards H2O2 as catalase mimics, and towards various phenols as functional RNR-R2 mimics, is described. Kinetic, mechanistic and computational studies gave direct evidence for the involvement of the (μ-1,2-peroxo)diiron(iii) intermediate in the O-H activation process via formation of low-spin oxoiron(iv) species.

Original languageEnglish
Pages (from-to)14709-14718
Number of pages10
JournalDalton Transactions
Volume45
Issue number37
DOIs
Publication statusPublished - 2016

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Enzyme kinetics
Phenols
Catalase
Chemical activation
benzimidazole

ASJC Scopus subject areas

  • Inorganic Chemistry

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Functional models of nonheme diiron enzymes : Kinetic and computational evidence for the formation of oxoiron(IV) species from peroxo-diiron(III) complexes, and their reactIVity towards phenols and H2O2. / Szávuly, Miklós István; Surducan, Mihai; Nagy, Emoke; Surányi, Mátyás; Speier, G.; Silaghi-Dumitrescu, Radu; Kaizer, J.

In: Dalton Transactions, Vol. 45, No. 37, 2016, p. 14709-14718.

Research output: Contribution to journalArticle

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AU - Szávuly, Miklós István

AU - Surducan, Mihai

AU - Nagy, Emoke

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AU - Speier, G.

AU - Silaghi-Dumitrescu, Radu

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