Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children

K. Horvatovich, S. Bokor, N. Polgar, P. Kisfali, F. Hadarits, L. Járomi, V. Csöngei, J. Repasy, D. Molnár, B. Melegh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The present study examined the possible associations of these variants with triglycerides and glucose levels, their allele distribution and their possible effects on childhood obesity. Methods and results: A total of 221 obese children and 115 healthy normal-weight children as controls were genotyped using PCR-RFLP methods. Both functional GCKR variants were found in association with elevated serum triglycerides and lower fasting plasma glucose levels. Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74). Conclusion: Our findings confirm the inverse modulating effect of functional GCKR variants on triglycerides and glucose levels in obese paediatric patients and healthy normal-weight controls. The results of our study strongly suggest that the minor alleles confer protection against the development of obesity in children. The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults.

Original languageEnglish
Pages (from-to)432-439
Number of pages8
JournalDiabetes and Metabolism
Volume37
Issue number5
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Glucokinase
Pediatric Obesity
Regulator Genes
Triglycerides
Glucose
Alleles
Fasting
Obesity
Weights and Measures
Restriction Fragment Length Polymorphisms
Type 2 Diabetes Mellitus
Logistic Models
glucokinase regulatory protein
Pediatrics
Polymerase Chain Reaction
Serum

Keywords

  • Children
  • Fasting plasma glucose
  • GCKR
  • Glucokinase Regulatory Protein
  • Obesity
  • Serum triglyceride

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children. / Horvatovich, K.; Bokor, S.; Polgar, N.; Kisfali, P.; Hadarits, F.; Járomi, L.; Csöngei, V.; Repasy, J.; Molnár, D.; Melegh, B.

In: Diabetes and Metabolism, Vol. 37, No. 5, 11.2011, p. 432-439.

Research output: Contribution to journalArticle

@article{7b97423606474fd6a4974e98f06a9c53,
title = "Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children",
abstract = "Objective: Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The present study examined the possible associations of these variants with triglycerides and glucose levels, their allele distribution and their possible effects on childhood obesity. Methods and results: A total of 221 obese children and 115 healthy normal-weight children as controls were genotyped using PCR-RFLP methods. Both functional GCKR variants were found in association with elevated serum triglycerides and lower fasting plasma glucose levels. Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95{\%} CI, 0.25-0.83; rs780094: OR, 0.41; 95{\%} CI, 0.23-0.74). Conclusion: Our findings confirm the inverse modulating effect of functional GCKR variants on triglycerides and glucose levels in obese paediatric patients and healthy normal-weight controls. The results of our study strongly suggest that the minor alleles confer protection against the development of obesity in children. The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults.",
keywords = "Children, Fasting plasma glucose, GCKR, Glucokinase Regulatory Protein, Obesity, Serum triglyceride",
author = "K. Horvatovich and S. Bokor and N. Polgar and P. Kisfali and F. Hadarits and L. J{\'a}romi and V. Cs{\"o}ngei and J. Repasy and D. Moln{\'a}r and B. Melegh",
year = "2011",
month = "11",
doi = "10.1016/j.diabet.2011.02.003",
language = "English",
volume = "37",
pages = "432--439",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "5",

}

TY - JOUR

T1 - Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children

AU - Horvatovich, K.

AU - Bokor, S.

AU - Polgar, N.

AU - Kisfali, P.

AU - Hadarits, F.

AU - Járomi, L.

AU - Csöngei, V.

AU - Repasy, J.

AU - Molnár, D.

AU - Melegh, B.

PY - 2011/11

Y1 - 2011/11

N2 - Objective: Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The present study examined the possible associations of these variants with triglycerides and glucose levels, their allele distribution and their possible effects on childhood obesity. Methods and results: A total of 221 obese children and 115 healthy normal-weight children as controls were genotyped using PCR-RFLP methods. Both functional GCKR variants were found in association with elevated serum triglycerides and lower fasting plasma glucose levels. Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74). Conclusion: Our findings confirm the inverse modulating effect of functional GCKR variants on triglycerides and glucose levels in obese paediatric patients and healthy normal-weight controls. The results of our study strongly suggest that the minor alleles confer protection against the development of obesity in children. The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults.

AB - Objective: Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The present study examined the possible associations of these variants with triglycerides and glucose levels, their allele distribution and their possible effects on childhood obesity. Methods and results: A total of 221 obese children and 115 healthy normal-weight children as controls were genotyped using PCR-RFLP methods. Both functional GCKR variants were found in association with elevated serum triglycerides and lower fasting plasma glucose levels. Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74). Conclusion: Our findings confirm the inverse modulating effect of functional GCKR variants on triglycerides and glucose levels in obese paediatric patients and healthy normal-weight controls. The results of our study strongly suggest that the minor alleles confer protection against the development of obesity in children. The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults.

KW - Children

KW - Fasting plasma glucose

KW - GCKR

KW - Glucokinase Regulatory Protein

KW - Obesity

KW - Serum triglyceride

UR - http://www.scopus.com/inward/record.url?scp=81055138738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81055138738&partnerID=8YFLogxK

U2 - 10.1016/j.diabet.2011.02.003

DO - 10.1016/j.diabet.2011.02.003

M3 - Article

C2 - 21511510

AN - SCOPUS:81055138738

VL - 37

SP - 432

EP - 439

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 5

ER -