Functional evidence that acetylcholine release from Auerbach's plexus of guinea-pig ileum is modulated by α2A-adrenoceptor subtype

Corrado Blandizzi, Margit Doda, Gabor Tarkovács, Mario Del Tacca, E. Sylvester Vizi

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26 Citations (Scopus)

Abstract

The effects of α2-adrenoceptor ligands on electrically stimulated [3H]acetylcholine release from longitudinal muscle strips of guinea-pig ileum were examined. Xylazine or oxymetazoline reduced the release of [3H]acetylcholine inn a concentration-dependent manner, both these actions being antagonized by idazoxan, CH 38083, or WB 4101. Prazosin. considered as an α2B-adrenoceptor antagonist, failed to modify the inhibitory effects of xylazine or oxymetazoline. It is concluded that the α2-adrenoceptors involved in the modulation of acetylcholine release from cholinergic axon terminals of guinea-pig ileum are of the α2A subtype.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalEuropean Journal of Pharmacology
Volume205
Issue number3
DOIs
Publication statusPublished - Dec 3 1991

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Keywords

  • Acetylcholine release
  • Ileum (guinea-pig)
  • Oxymetazoline
  • Prazosin
  • WB4101
  • α-Adrenoceptors
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Pharmacology

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