Functional deterioration of mouse liver ribosomes during aging: Translational activity and activity for formation of the 47 S initiation complex

Takashi Nakazawa, Nozomu Mori, S. Goto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The translational activities of ribosomes from young and old mouse livers were examined in an assay system dependent on rabbit globin mRNA. Old ribosomes showed 30-40% lower activity than young ribosomes. This observation, together with our previous findings (N. Mori, D. Mizuno and S. Goto, Mech. Ageing Dev., 10 (1979) 379-398), suggests functional deterioration of ribosomes of old animals. To examine the mechanism of the deterioration, the activities for formation of the initiation complex of 40 S ribosomal subunits in the livers of young and old mice were examined in vitro. The activity was found to be 15-20% lower in old mice (21 months old or more) than in young ones. This fact partly explains the decreased activity for ribosomal protein synthesis in old mice.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
JournalMechanisms of Ageing and Development
Volume26
Issue number2-3
DOIs
Publication statusPublished - 1984

Fingerprint

Ribosomes
Liver
Deterioration
Aging of materials
Globins
Ribosomal Proteins
Assays
Animals
Ribosome Subunits
Messenger RNA
Protein Biosynthesis
Rabbits

Keywords

  • Ageing
  • Globin mRNA
  • Initiation
  • Mouse
  • Ribosome
  • Translation

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Functional deterioration of mouse liver ribosomes during aging : Translational activity and activity for formation of the 47 S initiation complex. / Nakazawa, Takashi; Mori, Nozomu; Goto, S.

In: Mechanisms of Ageing and Development, Vol. 26, No. 2-3, 1984, p. 241-251.

Research output: Contribution to journalArticle

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