Functional consequences of retinopetal fibers originating in the dorsal raphe nucleus

Magor L. Lörincz, Márta Oláh, G. Juhász

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The existence of centrifugal fibers projecting into the mammalian retina is well known. However, their precise physiological role is poorly understood. Here we report that stimulation of the dorsal raphe nucleus (DRN) in freely moving rats produces profound effects on the electroretinogram (ERG). Most notably, activation of the dorsal raphe-retinal pathway causes a significant decrease in the latency of the b-wave and accompanying oscillatory potentials. In addition, dorsal raphe stimulation leads to a significant increase in the amplitude of oscillatory potentials. These results, therefore, provide the first demonstration of a functional role for the retinopetal fiber system originating in the and suggest that this structure can exert a powerful influence over the temporal sharpness and efficacy of retinal responsiveness.

Original languageEnglish
Pages (from-to)1374-1383
Number of pages10
JournalInternational Journal of Neuroscience
Volume118
Issue number10
DOIs
Publication statusPublished - Oct 2008

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Retina
Dorsal Raphe Nucleus

Keywords

  • B-wave
  • Electroretinogram
  • Freely moving rats
  • Oscillatory potentials
  • Retinal efferents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Functional consequences of retinopetal fibers originating in the dorsal raphe nucleus. / Lörincz, Magor L.; Oláh, Márta; Juhász, G.

In: International Journal of Neuroscience, Vol. 118, No. 10, 10.2008, p. 1374-1383.

Research output: Contribution to journalArticle

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