Functional and structural characterization of anti-β1-adrenoceptor autoantibodies of spontaneously hypertensive rats

Gerd Wallukat, Svenia Podlowski, Eberhard Nissen, Rosemarie Morwinski, Csaba Csonka, Arpad Tosaki, Ingolf E. Blasig

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the β1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the β1,-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the β1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-β1-adrenoceptor antibodies in the induction of human cardiomyopathy.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalMolecular and Cellular Biochemistry
Volume251
Issue number1-2
DOIs
Publication statusPublished - Sep 1 2003

Keywords

  • Autoantibodies
  • Cardiomyocytes
  • Heart failure
  • Spontaneously hypertensive rats
  • Β-adrenoceptor

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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