Functional and morphological changes in kidneys from marginal donors

B. Borda, E. Szederkényi, P. Szenohradszky, É Kemény, F. Marofka, C. Keresztes, G. Lázár

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Despite the increased number of cadaver donors and overall organ transplantations, we have observed a dramatic increase in the waiting list. We evaluated transplantations performed using marginal (n = 63) and "ideal" or optimal donors (n = 86). Donor and recipient functional and histopathological data were studied at 1 and 5 years after transplantation. Among the marginal donor group, we investigated whether the age or pre-existent hypertension in the donor showed a strong impact on the functional deterioration of the grafts. Twenty-three graftectomies were performed in marginal, and 39 in ideal recipients (P =.002). Evaluating graft function, at 5 years, we observed the serum creatinine level (P =.0001) and the estimated glomerular filtration rate (P =.003) are significantly different between the two groups. At this time there was a significant difference in the serum creatinine level of patients who were older than the age of 55 years compared with those who showed hypertension (P =.0003). Evaluating morphological changes in the kidneys, acute rejection episodes (P =.0004) and interstitial fibrosis/tubular atrophy (P =.002) were significantly greater among the marginal versus the ideal groups. At 1 year after kidney transplantation, despite no significant difference regarding renal function, they were significant in the histology of marginal versus ideal donor kidneys.

Original languageEnglish
Pages (from-to)2139-2142
Number of pages4
JournalTransplantation proceedings
Volume44
Issue number7
DOIs
Publication statusPublished - Sep 1 2012

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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