FUNKTIONALE ANALYSE IMMUNKOMPLEXREICHER SERUMFRAKTIONEN BEI AUTOIMMUNERKRANKUNGEN DURCH IN VITRO C3 AKTIVATION DES FRISCHEN PLASMAS

Translated title of the contribution: Functional activity analysis of circulating immune complexes in autoimmune diseases by in vitro activation of C3 in fresh plasma

U. Bohm, K. Meretey, A. Falus, S. Bozsoky

Research output: Contribution to journalArticle

Abstract

A method, measuring the activity of circulating immune complexes, based on C3 conversion of fresh human plasma by means of 3 per cent PEG precipitable immune complex-rich sera fractions is reported. Sera of patients suffering from autoimmune diseases of the connective tissue as well as of healthy controls were investigated. In case of standardised protein concentration of immune complexes, significantly low C3 conversion frequence of the isolated fractions has been observed in the control group as compared to the examined patients (rheumatoid arthritis with and without extraarticular manifestations, or juvenile chronic arthritis, or systemic lupus erythematosus). PEG fractions of RA with extraarticular manifestations induced the significantly highest C3 splitting. It is assumed that immune complexes will show a distinct interaction with the complement system also in vivo, and are therefore directly implicated in the systemic course of the disease process.

Original languageGerman
Pages (from-to)126-130
Number of pages5
JournalZeitschrift fur Rheumatologie
Volume40
Issue number3
Publication statusPublished - 1981

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Antigen-Antibody Complex
Autoimmune Diseases
Juvenile Arthritis
Serum
Systemic Lupus Erythematosus
Connective Tissue
Rheumatoid Arthritis
Control Groups
In Vitro Techniques
Proteins

ASJC Scopus subject areas

  • Rheumatology

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FUNKTIONALE ANALYSE IMMUNKOMPLEXREICHER SERUMFRAKTIONEN BEI AUTOIMMUNERKRANKUNGEN DURCH IN VITRO C3 AKTIVATION DES FRISCHEN PLASMAS. / Bohm, U.; Meretey, K.; Falus, A.; Bozsoky, S.

In: Zeitschrift fur Rheumatologie, Vol. 40, No. 3, 1981, p. 126-130.

Research output: Contribution to journalArticle

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