Terminology of carcinoid tumors has been changed during decades, and although its use in some areas of medicine still exists, nowadays this term has been replaced. According to the WHO classification, well differentiated neuroendocrine (NE) tumor, well differentiated neuroendocrine carcinoma and poorly differentiated neuroendocrine carcinoma are distinguished. In neuroendocrine tumors of the lung a somewhat different nomenclature is applied, these tumors are classified as typical and atypical carcinoids, or neuroendocrine carcinomas of large and small cell variants. In the NE tumors of different localization various genetic abnormalities are observed (point mutations, deletions, DNA methylations, chromosomal allel losses, etc.), even the gastro-entero-pancreatic tumors can not be generalized based on the molecular alterations. These facts raise the necessity of a more detailed classification. The author describes the diagnostic criteria in different organs, discusses the most important markers, the possible etiological factors, the diagnostic tools, and the therapeutic principles. In Hungary there are no exact data about the incidence of neuroendocrine tumors, and it would be important to centralize these patients in specialized centers, in order to diagnose and treat them upon the same regimen. Such a work is in progress by the Hungarian College of Gastroenterologists.
|Number of pages||9|
|Publication status||Published - Dec 1 2006|
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