From microspheres to monoliths

Synthesis of porous supports with tailored properties by radiation polymerization

Mariano Grasselli, Eduardo Smolko, P. Hargittai, Ágnes Sáfrány

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Advanced functional materials, both in shape of beads and monoliths, are in high demand for a variety of applications ranging from catalysis, chromatography, diagnostics, sensors to combinatorial chemistry. Here we report the synthesis of functional supports of different size and shape by radiation co-polymerization in organic solvents using diethylene glycol dimethacrylate (DEGDMA) and glycidylmethacrylate (GMA) as co-monomers. With the increase in the GMA content, the particle diameter increases from 0.9 to about 3 μm, while the yield decreases from 80% to 50%. The usefulness of the microspheres for immobilization was tested with histidine and lysosyme. Monoliths were prepared in situ as chromatographic columns. Our results showed that when a 30% monomer solution was irradiated, a 100% conversion of the monomer was obtainable with doses higher than 15 kGy. We showed the effect of dose and dose rate as well as the irradiation temperature on the pore size of the monoliths and the flux. The effect of such different solvents as tetrahydrofuran, ethylpropionate, acetone, methanol, ethanol, propanol and butanol is also discussed. Our results showed that radiation synthesis of porous polymer supports with epoxy functionality is a viable alternative to either thermally initiated or photo polymerization.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume185
Issue number1-4
DOIs
Publication statusPublished - Dec 2001

Fingerprint

Microspheres
polymerization
monomers
Monomers
Polymerization
Radiation
dosage
Dosimetry
radiation
synthesis
1-Propanol
Butanols
Functional materials
Photopolymerization
histidine
lysozyme
copolymerization
Propanol
chromatography
Muramidase

Keywords

  • Functional polymer microspheres
  • Immobilization
  • Monoliths
  • Purification
  • Radiation crosslinking
  • Radiation polymerization

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Instrumentation
  • Surfaces and Interfaces

Cite this

@article{cbebdf3a49574fb6ba69f931890be42d,
title = "From microspheres to monoliths: Synthesis of porous supports with tailored properties by radiation polymerization",
abstract = "Advanced functional materials, both in shape of beads and monoliths, are in high demand for a variety of applications ranging from catalysis, chromatography, diagnostics, sensors to combinatorial chemistry. Here we report the synthesis of functional supports of different size and shape by radiation co-polymerization in organic solvents using diethylene glycol dimethacrylate (DEGDMA) and glycidylmethacrylate (GMA) as co-monomers. With the increase in the GMA content, the particle diameter increases from 0.9 to about 3 μm, while the yield decreases from 80{\%} to 50{\%}. The usefulness of the microspheres for immobilization was tested with histidine and lysosyme. Monoliths were prepared in situ as chromatographic columns. Our results showed that when a 30{\%} monomer solution was irradiated, a 100{\%} conversion of the monomer was obtainable with doses higher than 15 kGy. We showed the effect of dose and dose rate as well as the irradiation temperature on the pore size of the monoliths and the flux. The effect of such different solvents as tetrahydrofuran, ethylpropionate, acetone, methanol, ethanol, propanol and butanol is also discussed. Our results showed that radiation synthesis of porous polymer supports with epoxy functionality is a viable alternative to either thermally initiated or photo polymerization.",
keywords = "Functional polymer microspheres, Immobilization, Monoliths, Purification, Radiation crosslinking, Radiation polymerization",
author = "Mariano Grasselli and Eduardo Smolko and P. Hargittai and {\'A}gnes S{\'a}fr{\'a}ny",
year = "2001",
month = "12",
doi = "10.1016/S0168-583X(01)00839-4",
language = "English",
volume = "185",
pages = "254--261",
journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",
issn = "0168-583X",
publisher = "Elsevier",
number = "1-4",

}

TY - JOUR

T1 - From microspheres to monoliths

T2 - Synthesis of porous supports with tailored properties by radiation polymerization

AU - Grasselli, Mariano

AU - Smolko, Eduardo

AU - Hargittai, P.

AU - Sáfrány, Ágnes

PY - 2001/12

Y1 - 2001/12

N2 - Advanced functional materials, both in shape of beads and monoliths, are in high demand for a variety of applications ranging from catalysis, chromatography, diagnostics, sensors to combinatorial chemistry. Here we report the synthesis of functional supports of different size and shape by radiation co-polymerization in organic solvents using diethylene glycol dimethacrylate (DEGDMA) and glycidylmethacrylate (GMA) as co-monomers. With the increase in the GMA content, the particle diameter increases from 0.9 to about 3 μm, while the yield decreases from 80% to 50%. The usefulness of the microspheres for immobilization was tested with histidine and lysosyme. Monoliths were prepared in situ as chromatographic columns. Our results showed that when a 30% monomer solution was irradiated, a 100% conversion of the monomer was obtainable with doses higher than 15 kGy. We showed the effect of dose and dose rate as well as the irradiation temperature on the pore size of the monoliths and the flux. The effect of such different solvents as tetrahydrofuran, ethylpropionate, acetone, methanol, ethanol, propanol and butanol is also discussed. Our results showed that radiation synthesis of porous polymer supports with epoxy functionality is a viable alternative to either thermally initiated or photo polymerization.

AB - Advanced functional materials, both in shape of beads and monoliths, are in high demand for a variety of applications ranging from catalysis, chromatography, diagnostics, sensors to combinatorial chemistry. Here we report the synthesis of functional supports of different size and shape by radiation co-polymerization in organic solvents using diethylene glycol dimethacrylate (DEGDMA) and glycidylmethacrylate (GMA) as co-monomers. With the increase in the GMA content, the particle diameter increases from 0.9 to about 3 μm, while the yield decreases from 80% to 50%. The usefulness of the microspheres for immobilization was tested with histidine and lysosyme. Monoliths were prepared in situ as chromatographic columns. Our results showed that when a 30% monomer solution was irradiated, a 100% conversion of the monomer was obtainable with doses higher than 15 kGy. We showed the effect of dose and dose rate as well as the irradiation temperature on the pore size of the monoliths and the flux. The effect of such different solvents as tetrahydrofuran, ethylpropionate, acetone, methanol, ethanol, propanol and butanol is also discussed. Our results showed that radiation synthesis of porous polymer supports with epoxy functionality is a viable alternative to either thermally initiated or photo polymerization.

KW - Functional polymer microspheres

KW - Immobilization

KW - Monoliths

KW - Purification

KW - Radiation crosslinking

KW - Radiation polymerization

UR - http://www.scopus.com/inward/record.url?scp=0035578050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035578050&partnerID=8YFLogxK

U2 - 10.1016/S0168-583X(01)00839-4

DO - 10.1016/S0168-583X(01)00839-4

M3 - Article

VL - 185

SP - 254

EP - 261

JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

SN - 0168-583X

IS - 1-4

ER -