From electric patterns to drugs

Perspectives of computational neuroscience in drug design

Tamás Kiss, P. Érdi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A novel way of computational modeling by integrating compartmental neural techniques and detailed kinetic description of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electro-physiological and behavioral effects of potential drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. Generation and pharamcological modulation of theta rhythm in area CA1 of the hippocampus related to anxiety is analyzed. Integrative modeling might help to find positive allosteric modulators of α1 subunits as potential candidates for being selective anxyolitics.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalBioSystems
Volume86
Issue number1-3
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Computational Neuroscience
Drug Design
neurophysiology
Neurosciences
Drugs
Modulation
drug
Hippocampus
drugs
Anxiety
Inverse Method
Computational Modeling
Modulator
Pharmaceutical Preparations
Theta Rhythm
Transmitter
Receptor
Modulators
Transmitters
Kinetics

Keywords

  • Compartmental modeling
  • Hippocampus
  • Reaction kinetics
  • Systems description
  • Theta oscillation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Drug Discovery

Cite this

From electric patterns to drugs : Perspectives of computational neuroscience in drug design. / Kiss, Tamás; Érdi, P.

In: BioSystems, Vol. 86, No. 1-3, 10.2006, p. 46-52.

Research output: Contribution to journalArticle

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