From coordination chemistry to biological chemistry of aluminium

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

The paper gives a review on the importance of distribution of Al in biological fluids, primarily in the lights of the works of the author in Al chemistry. It starts with studies of interactions of Al(III) with small biomolecules, such as aliphatic and aromatic hydroxycarboxylic acids, and inorganic and organic phosphates. A significant part of this review deals with the problems of description of the biospeciation of Al(III) in serum, where besides the thermodynamic conditions the role of time is also considered in the case of this sluggish metal ion. The Al(III) complexes of the other large group of biomolecules, proteins and their building blocks (oligo)peptides and amino acids are also discussed, where the role of the type of the side chain donors and the extent of preorganisation are considered in the efficiency of metal ion binding. The application of low molecular mass chelator molecules in restoring the dysfunctioning metal ion (including Al(III)) homeostasis in the treatment of Alzheimer's disease is also discussed in the paper.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume128
DOIs
Publication statusPublished - Jul 17 2013

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Keywords

  • Al complexes
  • Al in serum
  • Al-protein
  • Alzheimer's disease
  • Biospeciation

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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