Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations

Ágnes Szilágyi, Zsófia Bánlaki, Éva Pozsonyi, Edmond J. Yunis, Zuheir L. Awdeh, Adrienn Hossó, K. Rajczy, Charles E. Larsen, Dolores A. Fici, Chester A. Alper, G. Füst

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Abstract

Conserved extended haplotypes (CEHs) are large (≥1. Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasian families in comparison with the previous findings in 2675 normal American Caucasian chromosomes from families in the Boston area. Besides HLA-A, -B and HLA-DRB1/-DQB1 alleles, copy number polymorphism of C4A and C4B genes and several SNPs encoded in the central (class III) MHC region were determined.By comparing 188 Caucasian haplotypes in Hungary to 2675 normal Caucasian chromosomes in Boston, we found that 11 of 12 of the most common CEHs (with a frequency of at least 1%) among the Boston chromosomes also occurred in Hungary. Moreover, there was a significant correlation (R=0.789; p=0.0023) in the frequency order of these haplotypes between the two Caucasian populations. Of 10 haplotypes found in ≥2 copies among the Hungarian chromosomes, all but one occurred in one to 14 copies among the Boston haplotypes. These findings indicate that CEHs are commonly shared by distinct European Caucasian populations; however, lower frequency CEHs may differ.

Original languageEnglish
Pages (from-to)1899-1904
Number of pages6
JournalMolecular Immunology
Volume47
Issue number10
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Haplotypes
Population
Chromosomes
Major Histocompatibility Complex
Hungary
DNA Copy Number Variations
HLA-DRB1 Chains
HLA-A Antigens
Single Nucleotide Polymorphism
Alleles
DNA
Genes

Keywords

  • Complotype
  • Conserved extended haplotype
  • Family study
  • HLA
  • MHC

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Szilágyi, Á., Bánlaki, Z., Pozsonyi, É., Yunis, E. J., Awdeh, Z. L., Hossó, A., ... Füst, G. (2010). Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. Molecular Immunology, 47(10), 1899-1904. https://doi.org/10.1016/j.molimm.2010.03.013

Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. / Szilágyi, Ágnes; Bánlaki, Zsófia; Pozsonyi, Éva; Yunis, Edmond J.; Awdeh, Zuheir L.; Hossó, Adrienn; Rajczy, K.; Larsen, Charles E.; Fici, Dolores A.; Alper, Chester A.; Füst, G.

In: Molecular Immunology, Vol. 47, No. 10, 06.2010, p. 1899-1904.

Research output: Contribution to journalArticle

Szilágyi, Á, Bánlaki, Z, Pozsonyi, É, Yunis, EJ, Awdeh, ZL, Hossó, A, Rajczy, K, Larsen, CE, Fici, DA, Alper, CA & Füst, G 2010, 'Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations', Molecular Immunology, vol. 47, no. 10, pp. 1899-1904. https://doi.org/10.1016/j.molimm.2010.03.013
Szilágyi Á, Bánlaki Z, Pozsonyi É, Yunis EJ, Awdeh ZL, Hossó A et al. Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. Molecular Immunology. 2010 Jun;47(10):1899-1904. https://doi.org/10.1016/j.molimm.2010.03.013
Szilágyi, Ágnes ; Bánlaki, Zsófia ; Pozsonyi, Éva ; Yunis, Edmond J. ; Awdeh, Zuheir L. ; Hossó, Adrienn ; Rajczy, K. ; Larsen, Charles E. ; Fici, Dolores A. ; Alper, Chester A. ; Füst, G. / Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. In: Molecular Immunology. 2010 ; Vol. 47, No. 10. pp. 1899-1904.
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