Frequency of p53 codon 72 genotypes in human papillomavirus associated squamous intraepithelial lesions and cervical cancer

K. Szarka, G. Veress, József Kónya, L. Gergely

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. A recent study suggested that the p53Arg (at residue 72) homozygous genotype could be a potential genetic risk factor for cervical cancer among white women. To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous intraepithelial lesions (SIL) compared to a control population. Materials and Methods. We used allele-specific primers to amplify the p53Arg and p53Pro sequences and we examined the proportion of genotypes in the study populations using χ2-test. Results. The distributions of p53Arg homozygous, heterozygous and p53Pro homozygous genotypes were 63%, 27% and 10% in cervical cancer patients, 53%, 36% and 8% in individuals with SIL, and 60%, 36% and 4% in control population. Using chi-square test, no significant difference was found betweeen genotype frequencies in the study groups. Conclusion. Thus, the p53Arg homozygous genotype does not seem to increase the risk of cervical cancer in Hungarian women.

Original languageEnglish
Pages (from-to)2377-2379
Number of pages3
JournalAnticancer Research
Volume19
Issue number3 B
Publication statusPublished - 1999

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Codon
Uterine Cervical Neoplasms
Genotype
Population
Chi-Square Distribution
Squamous Intraepithelial Lesions of the Cervix
Alleles

Keywords

  • Cervical cancer
  • Human papillomavirus
  • p53 alleles
  • Risk factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Frequency of p53 codon 72 genotypes in human papillomavirus associated squamous intraepithelial lesions and cervical cancer",
abstract = "Background. A recent study suggested that the p53Arg (at residue 72) homozygous genotype could be a potential genetic risk factor for cervical cancer among white women. To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous intraepithelial lesions (SIL) compared to a control population. Materials and Methods. We used allele-specific primers to amplify the p53Arg and p53Pro sequences and we examined the proportion of genotypes in the study populations using χ2-test. Results. The distributions of p53Arg homozygous, heterozygous and p53Pro homozygous genotypes were 63{\%}, 27{\%} and 10{\%} in cervical cancer patients, 53{\%}, 36{\%} and 8{\%} in individuals with SIL, and 60{\%}, 36{\%} and 4{\%} in control population. Using chi-square test, no significant difference was found betweeen genotype frequencies in the study groups. Conclusion. Thus, the p53Arg homozygous genotype does not seem to increase the risk of cervical cancer in Hungarian women.",
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TY - JOUR

T1 - Frequency of p53 codon 72 genotypes in human papillomavirus associated squamous intraepithelial lesions and cervical cancer

AU - Szarka, K.

AU - Veress, G.

AU - Kónya, József

AU - Gergely, L.

PY - 1999

Y1 - 1999

N2 - Background. A recent study suggested that the p53Arg (at residue 72) homozygous genotype could be a potential genetic risk factor for cervical cancer among white women. To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous intraepithelial lesions (SIL) compared to a control population. Materials and Methods. We used allele-specific primers to amplify the p53Arg and p53Pro sequences and we examined the proportion of genotypes in the study populations using χ2-test. Results. The distributions of p53Arg homozygous, heterozygous and p53Pro homozygous genotypes were 63%, 27% and 10% in cervical cancer patients, 53%, 36% and 8% in individuals with SIL, and 60%, 36% and 4% in control population. Using chi-square test, no significant difference was found betweeen genotype frequencies in the study groups. Conclusion. Thus, the p53Arg homozygous genotype does not seem to increase the risk of cervical cancer in Hungarian women.

AB - Background. A recent study suggested that the p53Arg (at residue 72) homozygous genotype could be a potential genetic risk factor for cervical cancer among white women. To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous intraepithelial lesions (SIL) compared to a control population. Materials and Methods. We used allele-specific primers to amplify the p53Arg and p53Pro sequences and we examined the proportion of genotypes in the study populations using χ2-test. Results. The distributions of p53Arg homozygous, heterozygous and p53Pro homozygous genotypes were 63%, 27% and 10% in cervical cancer patients, 53%, 36% and 8% in individuals with SIL, and 60%, 36% and 4% in control population. Using chi-square test, no significant difference was found betweeen genotype frequencies in the study groups. Conclusion. Thus, the p53Arg homozygous genotype does not seem to increase the risk of cervical cancer in Hungarian women.

KW - Cervical cancer

KW - Human papillomavirus

KW - p53 alleles

KW - Risk factor

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