Frequency of acentric fragments are associated with cancer risk in subjects exposed to ionizing radiation

Aleksandra Fucic, Stefano Bonassi, S. Gundy, Juozas Lazutka, Radim Sram, Marcello Ceppi, Joe N. Lucas

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aim: Biomonitoring is currently applied in the estimation of health risks after overexposure to ionizing radiation (IR). The aim of this study was to compare the association of dicentric chromosomes and acentric fragments (AF) with cancer risk in subjects exposed to IR, as well as in control subjects. Materials and Methods: The study was performed on 3,574 subjects (2,030 subjects exposed to IR and 1,544 control subjects). The mean follow-up period was 8 years. Results: In subjects reporting exposure to IR, the presence of AFs and dicentric chromosomes was associated with a significant increase in cancer risk, hazard ratio (HR)=1.78 (95% confidence interval (CI)=1.01-3.13) and HR=1.73 (95% CI=1.03-2.90), respectively. Conclusion: AFs are associated with cancer risk and have a similar sensitivity to dicentric chromosomes in subjects exposed to IR. Because automated AF scoring can be easily introduced using fast flow cytometry combined with the pan-centromere staining, this biomarker may hold promise as a potential sensitive biomarker of exposure to IR and cancer risk.

Original languageEnglish
Pages (from-to)2451-2457
Number of pages7
JournalAnticancer Research
Volume36
Issue number5
Publication statusPublished - Jan 1 2016

Fingerprint

Ionizing Radiation
Neoplasms
Chromosomes
Biomarkers
Confidence Intervals
Centromere
Environmental Monitoring
Flow Cytometry
Odds Ratio
Staining and Labeling
Health

Keywords

  • Acentric fragments
  • Acentric fragments
  • Cancer risk
  • Carcinogenesis
  • Chromosomal aberrations
  • Chromosome damage
  • Ionizing radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fucic, A., Bonassi, S., Gundy, S., Lazutka, J., Sram, R., Ceppi, M., & Lucas, J. N. (2016). Frequency of acentric fragments are associated with cancer risk in subjects exposed to ionizing radiation. Anticancer Research, 36(5), 2451-2457.

Frequency of acentric fragments are associated with cancer risk in subjects exposed to ionizing radiation. / Fucic, Aleksandra; Bonassi, Stefano; Gundy, S.; Lazutka, Juozas; Sram, Radim; Ceppi, Marcello; Lucas, Joe N.

In: Anticancer Research, Vol. 36, No. 5, 01.01.2016, p. 2451-2457.

Research output: Contribution to journalArticle

Fucic, A, Bonassi, S, Gundy, S, Lazutka, J, Sram, R, Ceppi, M & Lucas, JN 2016, 'Frequency of acentric fragments are associated with cancer risk in subjects exposed to ionizing radiation', Anticancer Research, vol. 36, no. 5, pp. 2451-2457.
Fucic, Aleksandra ; Bonassi, Stefano ; Gundy, S. ; Lazutka, Juozas ; Sram, Radim ; Ceppi, Marcello ; Lucas, Joe N. / Frequency of acentric fragments are associated with cancer risk in subjects exposed to ionizing radiation. In: Anticancer Research. 2016 ; Vol. 36, No. 5. pp. 2451-2457.
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