Frequency-dependent effects of several class I antiarrhythmic drugs on Vmax of action potential upstroke in canine cardiac purkinje fibers

A. Varró, Victor Elharrar, Borys Surawicz

Research output: Contribution to journalArticle

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Abstract

Vmax of the action potential upstroke in canine cardiac Purkinje fibers was studied in the presence of seven class I antiarrhythmic drugs-lidocaine (4 μg/ml), mexiletine (4 μg/ml), propranolol (0.9 μg/ml), procainamide (30 μg/ml), quinidine (5 μg/ml), flecainide (4 μg/ml), and disopyramide (3.1 μg/ml)-at constant cycle lengths (CCL) and after abrupt changes in cycle length (ACCL). The time constant of Vmax recovery after ACCL at a basic cycle length of 500 ms was 0.09 ± 0.01 s for lidocaine, 0.18 ± 0.03 s for mexiletine, 1.35 ± 0.20 s for propranolol, 4.4 ± 0.8 s for procainamide, 8.3 ± 1.2 s for quinidine, 11.0 ± 0.9 s for flecainide, and 37.9 ± 9.4 s for disopyramide. These values were similar to those reported by others in guinea pig papillary muscle, and, with the exception of flecainide, conformed to the scheme proposed by Courtney (J Mol Cell Cardiol 1980;12:1273-86) based on the molecular weight and lipid solubility hypothesis. Each drug altered the Vmax differently at CCL from after ACCL at the same diastolic intervals. The magnitude of these differences and the range of diastolic intervals at which they were present varied among different drugs. These observations explain differences in the drug effects on the Vmax of the regularly and prematurely occurring depolarizations. In the presence of lidocaine and mexiletine, the recovery kinetics of Vmax were not altered by CCL within the 300-1,500-ms range, and the magnitude of Vmax depression was not influenced by action potential duration within the 200-270-ms range.

Original languageEnglish
Pages (from-to)482-492
Number of pages11
JournalJournal of Cardiovascular Pharmacology
Volume7
Issue number3
Publication statusPublished - 1985

Fingerprint

Mexiletine
Flecainide
Purkinje Fibers
Anti-Arrhythmia Agents
Lidocaine
Disopyramide
Action Potentials
Procainamide
Canidae
Quinidine
Propranolol
Pharmaceutical Preparations
Papillary Muscles
Solubility
Guinea Pigs
Molecular Weight
Lipids

Keywords

  • Action potential duration
  • Cardiac Purkinje fibers
  • Frequency dependence
  • Recovery kinetics of V<inf>max</inf>

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Frequency-dependent effects of several class I antiarrhythmic drugs on Vmax of action potential upstroke in canine cardiac purkinje fibers. / Varró, A.; Elharrar, Victor; Surawicz, Borys.

In: Journal of Cardiovascular Pharmacology, Vol. 7, No. 3, 1985, p. 482-492.

Research output: Contribution to journalArticle

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