Freeze-casting technique in the development of solid drug delivery systems

Anikó Szepes, Joachim Ulrich, Zsuzsanna Farkas, József Kovács, Piroska Szabó-Révész

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The aim of the present study was to develop a fast-dissolving solid dosage form containing theophylline as active ingredient using the freeze-casting technique. The structure, the physical properties and mechanism of drug release from the freeze-casted units were investigated. The examined properties of the samples were compared with those of tablets compressed by an eccentric tableting machine using three different compression pressures. The freeze-casting technique proved to be an appropriate alternative for the development of porous solid drug delivery systems. The mechanical strength of the matrices could be improved by using water-soluble additives, which stabilized the solid bodies during recrystallization upon drying. As compared with the tablets, the freeze-casted units revealed a highly porous nature and a remarkable difference in pore volume size distribution. The results demonstrated that the drug-solvent interaction, enhanced by the structural properties, resulted in a rapid delivery of the theophylline from the solid units into artificial gastric juice.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalChemical Engineering and Processing: Process Intensification
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

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Keywords

  • Crystallisation
  • Drug release
  • Freeze-casting
  • Porosity
  • SEM
  • Starch

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Energy Engineering and Power Technology
  • Industrial and Manufacturing Engineering

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