Free radical reactions and the endogenous antioxidant systems in essential hypertension

E. Rőth, J. Nemes, P. Kapronczay, G. Varga, M. T. Jaberansari, B. Borsiczky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Free radicals, in addition to directly influencing vascular smooth muscle, interact with vasoactive mediators produced by endothelial cells. Here we aimed to compare markers of oxidative stress in healthy individuals to those of patients with essential hypertension. The study included 20 healthy volunteers (group 1, mean age 24 ± 2 years), and 80 patients with hypertension (group 2, mean age 42 ± 12 years) further divided into WHO grade I patients (32) and WHO grade II patients (48). Malondialdehyde (MDA) concentration, activity of superoxide dismutase (SOD) and catalase, plus reduced and oxidised glutathione levels were measured in blood samples. Stimulated superoxide radical generating capacity of polymorphonuclear neutrophil granulocytes (PMN) was also determined. A higher MDA concentration was detected in group 2 (p <0.01), more so in patients with WHO grade II hypertension. Similarly, the activity of the antioxidant enzyme SOD was considerably elevated (p <0.001) in both WHO grade I and II hypertensive patients, while the rise in catalase activity was insignificant. The increase in glutathione level (p <0.05) also hinted at a compromise in the glutathione system. In addition, stimulated superoxide radical production of isolated PMNs was significantly (p <0.05) detectable in WHO grade II patients. These results are thought to suggest that free radical reactions have an important role in the pathogenesis of hypertension, and their monitoring may help in evaluating the actual state of disease as well as the efficacy of antihypertensive drugs.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalEuropean Journal of Internal Medicine
Volume9
Issue number4
Publication statusPublished - 1998

Fingerprint

Free Radicals
Antioxidants
Glutathione
Hypertension
Malondialdehyde
Superoxides
Catalase
Superoxide Dismutase
Glutathione Disulfide
Essential Hypertension
Vascular Smooth Muscle
Granulocytes
Antihypertensive Agents
Healthy Volunteers
Oxidative Stress
Neutrophils
Endothelial Cells
Enzymes

Keywords

  • Antioxidant enzymes
  • Hypertension
  • Lipid peroxidation
  • Neutrophil functions
  • Superoxide radical production

ASJC Scopus subject areas

  • Medicine(all)
  • Internal Medicine

Cite this

Free radical reactions and the endogenous antioxidant systems in essential hypertension. / Rőth, E.; Nemes, J.; Kapronczay, P.; Varga, G.; Jaberansari, M. T.; Borsiczky, B.

In: European Journal of Internal Medicine, Vol. 9, No. 4, 1998, p. 263-270.

Research output: Contribution to journalArticle

Rőth, E. ; Nemes, J. ; Kapronczay, P. ; Varga, G. ; Jaberansari, M. T. ; Borsiczky, B. / Free radical reactions and the endogenous antioxidant systems in essential hypertension. In: European Journal of Internal Medicine. 1998 ; Vol. 9, No. 4. pp. 263-270.
@article{4ab295279c7a4bdca578d5553fe2e8bf,
title = "Free radical reactions and the endogenous antioxidant systems in essential hypertension",
abstract = "Free radicals, in addition to directly influencing vascular smooth muscle, interact with vasoactive mediators produced by endothelial cells. Here we aimed to compare markers of oxidative stress in healthy individuals to those of patients with essential hypertension. The study included 20 healthy volunteers (group 1, mean age 24 ± 2 years), and 80 patients with hypertension (group 2, mean age 42 ± 12 years) further divided into WHO grade I patients (32) and WHO grade II patients (48). Malondialdehyde (MDA) concentration, activity of superoxide dismutase (SOD) and catalase, plus reduced and oxidised glutathione levels were measured in blood samples. Stimulated superoxide radical generating capacity of polymorphonuclear neutrophil granulocytes (PMN) was also determined. A higher MDA concentration was detected in group 2 (p <0.01), more so in patients with WHO grade II hypertension. Similarly, the activity of the antioxidant enzyme SOD was considerably elevated (p <0.001) in both WHO grade I and II hypertensive patients, while the rise in catalase activity was insignificant. The increase in glutathione level (p <0.05) also hinted at a compromise in the glutathione system. In addition, stimulated superoxide radical production of isolated PMNs was significantly (p <0.05) detectable in WHO grade II patients. These results are thought to suggest that free radical reactions have an important role in the pathogenesis of hypertension, and their monitoring may help in evaluating the actual state of disease as well as the efficacy of antihypertensive drugs.",
keywords = "Antioxidant enzymes, Hypertension, Lipid peroxidation, Neutrophil functions, Superoxide radical production",
author = "E. Rőth and J. Nemes and P. Kapronczay and G. Varga and Jaberansari, {M. T.} and B. Borsiczky",
year = "1998",
language = "English",
volume = "9",
pages = "263--270",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Free radical reactions and the endogenous antioxidant systems in essential hypertension

AU - Rőth, E.

AU - Nemes, J.

AU - Kapronczay, P.

AU - Varga, G.

AU - Jaberansari, M. T.

AU - Borsiczky, B.

PY - 1998

Y1 - 1998

N2 - Free radicals, in addition to directly influencing vascular smooth muscle, interact with vasoactive mediators produced by endothelial cells. Here we aimed to compare markers of oxidative stress in healthy individuals to those of patients with essential hypertension. The study included 20 healthy volunteers (group 1, mean age 24 ± 2 years), and 80 patients with hypertension (group 2, mean age 42 ± 12 years) further divided into WHO grade I patients (32) and WHO grade II patients (48). Malondialdehyde (MDA) concentration, activity of superoxide dismutase (SOD) and catalase, plus reduced and oxidised glutathione levels were measured in blood samples. Stimulated superoxide radical generating capacity of polymorphonuclear neutrophil granulocytes (PMN) was also determined. A higher MDA concentration was detected in group 2 (p <0.01), more so in patients with WHO grade II hypertension. Similarly, the activity of the antioxidant enzyme SOD was considerably elevated (p <0.001) in both WHO grade I and II hypertensive patients, while the rise in catalase activity was insignificant. The increase in glutathione level (p <0.05) also hinted at a compromise in the glutathione system. In addition, stimulated superoxide radical production of isolated PMNs was significantly (p <0.05) detectable in WHO grade II patients. These results are thought to suggest that free radical reactions have an important role in the pathogenesis of hypertension, and their monitoring may help in evaluating the actual state of disease as well as the efficacy of antihypertensive drugs.

AB - Free radicals, in addition to directly influencing vascular smooth muscle, interact with vasoactive mediators produced by endothelial cells. Here we aimed to compare markers of oxidative stress in healthy individuals to those of patients with essential hypertension. The study included 20 healthy volunteers (group 1, mean age 24 ± 2 years), and 80 patients with hypertension (group 2, mean age 42 ± 12 years) further divided into WHO grade I patients (32) and WHO grade II patients (48). Malondialdehyde (MDA) concentration, activity of superoxide dismutase (SOD) and catalase, plus reduced and oxidised glutathione levels were measured in blood samples. Stimulated superoxide radical generating capacity of polymorphonuclear neutrophil granulocytes (PMN) was also determined. A higher MDA concentration was detected in group 2 (p <0.01), more so in patients with WHO grade II hypertension. Similarly, the activity of the antioxidant enzyme SOD was considerably elevated (p <0.001) in both WHO grade I and II hypertensive patients, while the rise in catalase activity was insignificant. The increase in glutathione level (p <0.05) also hinted at a compromise in the glutathione system. In addition, stimulated superoxide radical production of isolated PMNs was significantly (p <0.05) detectable in WHO grade II patients. These results are thought to suggest that free radical reactions have an important role in the pathogenesis of hypertension, and their monitoring may help in evaluating the actual state of disease as well as the efficacy of antihypertensive drugs.

KW - Antioxidant enzymes

KW - Hypertension

KW - Lipid peroxidation

KW - Neutrophil functions

KW - Superoxide radical production

UR - http://www.scopus.com/inward/record.url?scp=0032460925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032460925&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032460925

VL - 9

SP - 263

EP - 270

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

IS - 4

ER -