Free radical mediated injuries after coronary artery occlusion

E. Röth, B. Török, D. Kelemen, S. Pollák

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The left descending coronary artery (LAD) of mongrel dogs was ligated for one month to evaluate the effect of a dihydroquinoline-type antioxidant (MTDQ-DA) during the healing process of myocardial infarction. Thirty animals were divided into three groups: I) control animals (10 dogs) were treated with saline infusion during operation and postoperative days; II) 10 dogs were treated with intravenous MTDQ-DA during the operation followed by postoperative oral treatment, and III) 10 animals were treated with preoperative and postoperative oral treatment plus intraoperative MTDQ-DA infusion. The antioxidant effects were evaluated by measurements of the lipid peroxidation end product malondialdehyde (MDA) and of endogenous scavengers: reduced glutathione (GSH) and superoxide dismutase (SOD) in the ischemic and in intact areas. Ultrathin sections were investigated by JEOL 100 C electron microscope. Elevation of lipid peroxidation (LPO) was present in each group. The most remarkable changes were seen in the control ischemic areas (152±6.7%). GSH was depleted in the infarcted areas of the control hearts (60±5.6%), in the antioxidant treated animals this thiol compound was only slightly decreased (81±5.6%). SOD activity showed a sharp decline (group I) in both ischemic (52±8.3 U/g) and non-ischemic parts of the left ventricle (78±7 U/g). After MTDQ-DA treatment (groups II, III) SOD activity diminished only in the ischemic area (83±8.5 U/g); other parts showed normal (123±7.2 U/g) activity. According to ultrastructural examinations, MTDQ-DA diminished the degree of structural injury.

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalBasic research in cardiology
Volume84
Issue number4
DOIs
Publication statusPublished - Jul 1 1989

Keywords

  • lipid peroxidation
  • {ie561-1}yocardial ischemia
  • {ie561-2}ardiac ultrastructure
  • {ie561-3}ntioxidant treatment

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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