Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy

Pekka Kannus, L. Józsa, Teppo L N Järvinen, Martti Kvist, Toini Vieno, Tero A H Järvinen, Antero Natri, Markku Järvinen

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

After 3 wk of immobilization, the effects of free cage activity and low- and high-intensity treadmill running (8 wk) on the morphology and histochemistry of the soleus and gastrocnemius muscles in male Sprague- Dawley rats were investigated. In both muscles, immobilization produced a significant (P <0.001) increase in the mean percent area of intramuscular connective tissue (soleus: 18.9% in immobilized left hindlimb vs. 3.6% in nonimmobilized right hindlimb) and in the relative number of muscle fibers with pathological alterations (soleus: 66% in immobilized hindlimb vs. 6% in control), with a simultaneous significant (P <0.001) decrease in the intramuscular capillary density (soleus: mean capillary density in the immobilized hindlimb only 63% of that in the nonimmobilized hindlimb) and muscle fiber size (soleus type I fibers: mean fiber size in the immobilized hindlimb only 69% of that in the nonimmobilized hindlimb). Many of these changes could not be corrected by free remobilization, whereas low- and high- intensity treadmill running clearly restored the changes toward control levels, the effect being most complete in the high-intensity running group. Collectively, these findings indicate that immobilization-induced pathological structure and histochemical alterations in rat calf muscles are, to a great extent, reversible phenomena if remobilization is intensified by physical training, in this respect, high-intensity exercise seems more beneficial than low-intensity exercise.

Original languageEnglish
Pages (from-to)1418-1424
Number of pages7
JournalJournal of Applied Physiology
Volume84
Issue number4
Publication statusPublished - Apr 1998

Fingerprint

Muscular Atrophy
Hindlimb
Immobilization
Running
Muscles
Skeletal Muscle
Connective Tissue
Sprague Dawley Rats

Keywords

  • Capillary number
  • Fiber changes
  • Intramuscular connective tissue
  • Rats
  • Remobilization
  • Soleus and gastrocnemius muscles

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Kannus, P., Józsa, L., Järvinen, T. L. N., Kvist, M., Vieno, T., Järvinen, T. A. H., ... Järvinen, M. (1998). Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy. Journal of Applied Physiology, 84(4), 1418-1424.

Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy. / Kannus, Pekka; Józsa, L.; Järvinen, Teppo L N; Kvist, Martti; Vieno, Toini; Järvinen, Tero A H; Natri, Antero; Järvinen, Markku.

In: Journal of Applied Physiology, Vol. 84, No. 4, 04.1998, p. 1418-1424.

Research output: Contribution to journalArticle

Kannus, P, Józsa, L, Järvinen, TLN, Kvist, M, Vieno, T, Järvinen, TAH, Natri, A & Järvinen, M 1998, 'Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy', Journal of Applied Physiology, vol. 84, no. 4, pp. 1418-1424.
Kannus P, Józsa L, Järvinen TLN, Kvist M, Vieno T, Järvinen TAH et al. Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy. Journal of Applied Physiology. 1998 Apr;84(4):1418-1424.
Kannus, Pekka ; Józsa, L. ; Järvinen, Teppo L N ; Kvist, Martti ; Vieno, Toini ; Järvinen, Tero A H ; Natri, Antero ; Järvinen, Markku. / Free mobilization and low- to high-intensity exercise in immobilization- induced muscle atrophy. In: Journal of Applied Physiology. 1998 ; Vol. 84, No. 4. pp. 1418-1424.
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