Szabad DNS-alapú vastagbéldaganat-szurés perifériás vérbol: a metilált szeptin-9 génmarker lehetoségei

Translated title of the contribution: Free circulating DNA based colorectal cancer screening from peripheral blood: The possibility of the methylated septin 9 gene marker

Kinga Tóth, O. Galamb, S. Spisák, Barnabás Wichmann, F. Sípos, Katalin Leiszter, Jeannette Molnár, B. Molnár, Z. Tulassay

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.

Original languageHungarian
Pages (from-to)969-977
Number of pages9
JournalOrvosi Hetilap
Volume150
Issue number21
DOIs
Publication statusPublished - May 1 2009

Fingerprint

Septins
Early Detection of Cancer
Colorectal Neoplasms
DNA
Genes
Hematologic Diseases
DNA Methylation
Cytoskeleton
Methylation
Carcinogenesis
Breast Neoplasms
Research
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szabad DNS-alapú vastagbéldaganat-szurés perifériás vérbol : a metilált szeptin-9 génmarker lehetoségei. / Tóth, Kinga; Galamb, O.; Spisák, S.; Wichmann, Barnabás; Sípos, F.; Leiszter, Katalin; Molnár, Jeannette; Molnár, B.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 150, No. 21, 01.05.2009, p. 969-977.

Research output: Contribution to journalArticle

@article{ebad52a313e0467fbdf7ffc29c232e67,
title = "Szabad DNS-alap{\'u} vastagb{\'e}ldaganat-szur{\'e}s perif{\'e}ri{\'a}s v{\'e}rbol: a metil{\'a}lt szeptin-9 g{\'e}nmarker lehetos{\'e}gei",
abstract = "DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.",
keywords = "Colorectal cancer, Free circulating DNA, Methylation, Peripheral blood, Septin 9",
author = "Kinga T{\'o}th and O. Galamb and S. Spis{\'a}k and Barnab{\'a}s Wichmann and F. S{\'i}pos and Katalin Leiszter and Jeannette Moln{\'a}r and B. Moln{\'a}r and Z. Tulassay",
year = "2009",
month = "5",
day = "1",
doi = "10.1556/OH.2009.28625",
language = "Hungarian",
volume = "150",
pages = "969--977",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "21",

}

TY - JOUR

T1 - Szabad DNS-alapú vastagbéldaganat-szurés perifériás vérbol

T2 - a metilált szeptin-9 génmarker lehetoségei

AU - Tóth, Kinga

AU - Galamb, O.

AU - Spisák, S.

AU - Wichmann, Barnabás

AU - Sípos, F.

AU - Leiszter, Katalin

AU - Molnár, Jeannette

AU - Molnár, B.

AU - Tulassay, Z.

PY - 2009/5/1

Y1 - 2009/5/1

N2 - DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.

AB - DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.

KW - Colorectal cancer

KW - Free circulating DNA

KW - Methylation

KW - Peripheral blood

KW - Septin 9

UR - http://www.scopus.com/inward/record.url?scp=66149110301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149110301&partnerID=8YFLogxK

U2 - 10.1556/OH.2009.28625

DO - 10.1556/OH.2009.28625

M3 - Article

C2 - 19443305

AN - SCOPUS:66149110301

VL - 150

SP - 969

EP - 977

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 21

ER -