Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men

Results from the european male aging study

Abdelouahid Tajar, Matthew D L O'Connell, Arnold B. Mitnitski, Terence W. O'Neill, Samuel D. Searle, Ilpo T. Huhtaniemi, Joseph D. Finn, G. Bártfai, Steven Boonen, Felipe F. Casanueva, Gianni Forti, Aleksander Giwercman, Thang S. Han, Krzysztof Kula, Fernand Labrie, Michael E J Lean, Neil Pendleton, Margus Punab, Alan J. Silman, Dirk Vanderschueren & 2 others Kenneth Rockwood, Frederick C W Wu

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objectives: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. Design: Cross-sectional. Setting: The European Male Aging Study. Participants: Three thousand two hundred nineteen community-dwelling European men aged 40 to 79. Measurements: Interviewer-assisted questionnaires to assess physical activity, health status, and mood were administered. Testosterone (T), luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were measured in a fasting morning blood sample. Frailty was assessed as an index (FI) according to the number (out of 43 possible) of health deficits (symptoms, signs, and functional impairments). Relationships between FI and hormone levels (as outcomes) were explored using regression models. Results: Mean FI was 0.12 ± 0.11 (range 0-0.67) was highest in the oldest group. After adjustment for confounders, higher levels of FI were significantly associated with lower levels of total T, free T, and DHEAS and higher levels of gonadotropins and SHBG; a 1-standard deviation cross-sectional increase in FI was associated with a regression coefficient of -0.30 nmol/L (95% confidence interval (CI)=-0.53 to -0.07) decrease in total T and 0.66 U/L (95% CI=0.48-0.83) increase in LH. ConclusionS: The associations between high FI, high gonadotropins, and well-maintained circulating T suggest that these changes are markers of aging-related disruptions of multiple physiological regulation, of which alterations in pituitary-testicular function represent a sensitive marker rather than an underlying pathogenic mechanism for frailty.

Original languageEnglish
Pages (from-to)814-821
Number of pages8
JournalJournal of the American Geriatrics Society
Volume59
Issue number5
DOIs
Publication statusPublished - May 2011

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Hypothalamic Hormones
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Luteinizing Hormone
Gonadotropins
Hormones
Confidence Intervals
Independent Living
Follicle Stimulating Hormone
Health Status
Signs and Symptoms
Testosterone
Fasting
Interviews
Exercise
Health
Surveys and Questionnaires

Keywords

  • EMAS
  • epidemiology
  • frailty index
  • hypothalamic-pituitary-testicular axis
  • testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men : Results from the european male aging study. / Tajar, Abdelouahid; O'Connell, Matthew D L; Mitnitski, Arnold B.; O'Neill, Terence W.; Searle, Samuel D.; Huhtaniemi, Ilpo T.; Finn, Joseph D.; Bártfai, G.; Boonen, Steven; Casanueva, Felipe F.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Rockwood, Kenneth; Wu, Frederick C W.

In: Journal of the American Geriatrics Society, Vol. 59, No. 5, 05.2011, p. 814-821.

Research output: Contribution to journalArticle

Tajar, A, O'Connell, MDL, Mitnitski, AB, O'Neill, TW, Searle, SD, Huhtaniemi, IT, Finn, JD, Bártfai, G, Boonen, S, Casanueva, FF, Forti, G, Giwercman, A, Han, TS, Kula, K, Labrie, F, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Vanderschueren, D, Rockwood, K & Wu, FCW 2011, 'Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men: Results from the european male aging study', Journal of the American Geriatrics Society, vol. 59, no. 5, pp. 814-821. https://doi.org/10.1111/j.1532-5415.2011.03398.x
Tajar, Abdelouahid ; O'Connell, Matthew D L ; Mitnitski, Arnold B. ; O'Neill, Terence W. ; Searle, Samuel D. ; Huhtaniemi, Ilpo T. ; Finn, Joseph D. ; Bártfai, G. ; Boonen, Steven ; Casanueva, Felipe F. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Kula, Krzysztof ; Labrie, Fernand ; Lean, Michael E J ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J. ; Vanderschueren, Dirk ; Rockwood, Kenneth ; Wu, Frederick C W. / Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men : Results from the european male aging study. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 5. pp. 814-821.
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AU - Mitnitski, Arnold B.

AU - O'Neill, Terence W.

AU - Searle, Samuel D.

AU - Huhtaniemi, Ilpo T.

AU - Finn, Joseph D.

AU - Bártfai, G.

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