Formulation study of directly compressible chewable polymers containing ascorbic acid

P. Kása, I. Jójárt, A. Kelemen, K. Pintye-Hódi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gum tablets by direct compression. Three different gum bases, Pharmagum® C, M and S, were tested alone and in different combinations. The preparations were compressed with a Korsch EK0 eccentric tableting machine at compression forces of 5, 7.5, 10, 12.5 and 15 kN. The compression and breaking processes and the physical parameters of the tablets were investigated. The results revealed that increase of the compression force did not significantly change the studied parameters of the tablets.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalPharmaceutical Development and Technology
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Ascorbic acid
  • Chewing gum
  • Deformation
  • Direct compression
  • Dissolution
  • Pharmagum

ASJC Scopus subject areas

  • Pharmaceutical Science

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