Intraorális gyógyszerformák fejlesztési lehetőségei

Translated title of the contribution: Formulation strategies of intraoral dosage forms

Kállai Nikolett, Sebestyén Zita, Szabó Barnab́as, Simon Viktória, Antal István, Zelkó Roḿana

Research output: Contribution to journalReview article

Abstract

The active pharmaceutical ingredient can be administered by several different routes. Although the oral route (per os) has been one of the most convenient and widely accepted delivery system for most drugs, it has number of disadvantages like the very low pH of the stomach, the high enzymatic activity, and extensive first-pass metabolism. Difficulty in swallowing (dysphagia) is common among all age groups, especially in "problematical" subpopulations like children and the elderly. Several novel intraoral dosage forms (IODs) have recently become available to modulate the physicochemical and pharmacokinetic characteristics of drugs, while improving patient compliance. The present article summarizes and categorizes their formulation possibilities.

Translated title of the contributionFormulation strategies of intraoral dosage forms
Original languageHungarian
Pages (from-to)95-103
Number of pages9
JournalActa pharmaceutica Hungarica
Volume82
Issue number3
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Nikolett, K., Zita, S., Barnab́as, S., Viktória, S., István, A., & Roḿana, Z. (2012). Intraorális gyógyszerformák fejlesztési lehetőségei. Acta pharmaceutica Hungarica, 82(3), 95-103.