Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation

Á Makó, G. Csóka, E. Pásztor, S. Marton, G. Horvai, I. Klebovich

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of this study was the formulation and examination of a novel thermoresponsive and bioadhesive, in situ gelling drug delivery system, which can be used in the treatment of oesophageal pain and inflammation. A bioadhesive cellulose derivative (Metolose® 60SH) was used as a thermoresponsive material, because Metolose® has thermal gelation properties at certain temperature. The thermal gelation temperature (T2) of Metolose® 60SH 2 w/w% solution is above body temperature (65-66 °C), but by using different methods (Metolose® 60SH concentration, auxiliary materials), it can be shifted near to body temperature. The pH alteration between pH = 2-10 and the application of different alcohols did not influence the gelation temperature, but using water-soluble salts and changing the concentration of Metolose® 60SH solution between 2 and 3 w/w% the thermal gelation point could be decreased. Different NSAIDs were used as model drugs and which had not influence on thermal gelation temperature, but difference in in vitro liberation and penetration can be observed. In vitro adhesion test pointed out that the condition of investigated membrane can change the adhesion. Morphological test of oesophageal tissue showed that investigated materials had no irritative or tissue-damaging effect on the oesophageal mucosa even after 12 h.

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume72
Issue number1
DOIs
Publication statusPublished - May 2009

Fingerprint

Hot Temperature
Gels
Inflammation
Pain
Temperature
Body Temperature
Non-Steroidal Anti-Inflammatory Agents
Therapeutics
Drug Delivery Systems
Cellulose
Salts
Alcohols
Membranes
Water
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • Bioadhesive
  • In-situ gelling
  • Metolose 60SH
  • NSAID
  • Oesophagus
  • Thermoresponsive

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation. / Makó, Á; Csóka, G.; Pásztor, E.; Marton, S.; Horvai, G.; Klebovich, I.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 72, No. 1, 05.2009, p. 260-265.

Research output: Contribution to journalArticle

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