Formulation of poorly water-soluble Gemfibrozil applying power ultrasound

R. Ambrus, N. Naghipour Amirzadi, Z. Aigner, P. Szabó-Révész

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The dissolution properties of a drug and its release from the dosage form have a basic impact on its bioavailability. Solubility problems are a major challenge for the pharmaceutical industry as concerns the development of new pharmaceutical products. Formulation problems may possibly be overcome by modification of particle size and morphology. The application of power ultrasound is a novel possibility in drug formulation. This article reports on solvent diffusion and melt emulsification, as new methods supplemented with drying in the field of sonocrystallization of poorly water-soluble Gemfibrozil. During thermoanalytical characterization, a modified structure was detected. The specific surface area of the drug was increased following particle size reduction and the poor wettability properties could also be improved. The dissolution rate was therefore significantly increased.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalUltrasonics Sonochemistry
Volume19
Issue number2
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Gemfibrozil
Particle Size
Drug products
Dissolution
drugs
Ultrasonics
Particle size
Wettability
formulations
Drug Compounding
Emulsification
Water
Dosage Forms
Drug Industry
dissolving
Specific surface area
Pharmaceutical Preparations
Solubility
water
Biological Availability

Keywords

  • Dissolution
  • Particle size reduction
  • Power ultrasound
  • Sonocrystallization

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Acoustics and Ultrasonics
  • Radiology Nuclear Medicine and imaging

Cite this

Formulation of poorly water-soluble Gemfibrozil applying power ultrasound. / Ambrus, R.; Amirzadi, N. Naghipour; Aigner, Z.; Szabó-Révész, P.

In: Ultrasonics Sonochemistry, Vol. 19, No. 2, 03.2012, p. 286-291.

Research output: Contribution to journalArticle

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