New soft-patch gel systems containing non-steroidal anti-inflammatory drugs (NSAID) were examined: diclofenac sodium, ibuprofen, piroxicam for topical application. Soft patch gel system consists of very thin, flexible, single-dose units covered by a film. This soft patch can be fixed on the skin and proves good percutan absorption of the drugs. In vitro liberation and percutan absorption from different gel systems (stearate, PEG, lipophilic gels) were studied and the effect of some auxiliary materials was examined. In vitro liberation tests were done by ointment cell, acceptor medium was pH 6 buffer solution. Absorption rate constants were determined by Sartorius Resorptionsmodell apparatus, acceptor medium was pH 7.5 buffer solution. Optimizing the composition of the gel system amounts of propylene glycol as viscosity-enhancing agent and stearic acid as gel-forming agent were changed. The most appropriate liberation and absorption characteristics were observed in the case of the hydrophilic gel system.
|Number of pages||4|
|Journal||Drugs Made in Germany|
|Publication status||Published - Jan 1 1999|
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)