Formulation of diazepam suppositories, results of the rheological and biopharmaceutical studies. I. Rheological study of the used suppository bases

I. Erös, I. Bácskay, G. Regdon, B. Selmeczi

Research output: Contribution to journalArticle

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Abstract

The rheological properties of four lipophilic and three hydrophilic suppository bases were studied. The flow and viscosity curves, the initial, equilibrium and plastic viscosity as well as the Bingham's yield value of the systems were determined. It was found that the viscosity curves had two different parts in the examined shearing rate range: the part of greater rise described a definitive destruction of the system, while the part of smaller rise represented an equilibrium state. The values of the rheological parameters of the lipophilic and hydrophilic systems showed a definite difference, which was explained by the greater association of the hydrophilic bases.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalActa Pharmaceutica Hungarica
Volume63
Issue number5
Publication statusPublished - 1993

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Suppositories
Diazepam
Viscosity
Plastics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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AU - Bácskay, I.

AU - Regdon, G.

AU - Selmeczi, B.

PY - 1993

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AB - The rheological properties of four lipophilic and three hydrophilic suppository bases were studied. The flow and viscosity curves, the initial, equilibrium and plastic viscosity as well as the Bingham's yield value of the systems were determined. It was found that the viscosity curves had two different parts in the examined shearing rate range: the part of greater rise described a definitive destruction of the system, while the part of smaller rise represented an equilibrium state. The values of the rheological parameters of the lipophilic and hydrophilic systems showed a definite difference, which was explained by the greater association of the hydrophilic bases.

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