Humán interferon-α orális szilárd gyógyszerformába történo feldolgozása

Translated title of the contribution: Formulation of an oral solid dosage form containing human interferon-α

Kristó Katalin, Bajdik János, Márki Árpád, Eros István, Falkay György, Hódi Klára

Research output: Contribution to journalArticle

2 Citations (Scopus)


The main objective of this study was to process the human á-interferon for the solid dosage form. The first step was the preparation of the intermediate product for the tablet making. Fluid bed apparatus with top spray method was applied for the layering of powdered cellulose with human α-interferon solutions. The intermediate product was compressed into tablet and an enteric solvent coating of the tablets was made in a fluid bed apparatus with Wurster method. The physical parameters were detected. These fitted the Ph. Eur. and the mechanical properties of the tablets were appropriate for coating in fluid bed apparatus. The tablets agree with the requirements of Ph. Eur. and the active agent was not dissolved in gastric juice. An animal test was also performed. The human α-interferon in the blood of the animals was detected with ELISA method. The human α-interferon specific kit was used. The active ingredient dissolved from the tablets was absorbed from the ileum. The solid dosage form containing human α-interferon was prepared; this can make oral application of human α-interferon possible.

Translated title of the contributionFormulation of an oral solid dosage form containing human interferon-α
Original languageHungarian
Pages (from-to)31-35
Number of pages5
JournalActa pharmaceutica Hungarica
Issue number1
Publication statusPublished - Apr 11 2008

ASJC Scopus subject areas

  • Pharmaceutical Science

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