Formation of spherical iron(III) oxyhydroxide nanoparticles sterically stabilized by chitosan in aqueous solutions

P. Sipos, O. Berkesi, E. Tombácz, Tim G. St. Pierre, John Webb

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The interactions between the cationic polymer chitosan (Chit) and iron(III) were investigated. The solution properties were studied by pH-metry, viscometry and dynamic light scattering. Solid state iron(III)-Chit samples were also prepared and characterized by IR spectroscopy and electron microscopy. In aqueous solutions, the precipitation pH of the iron(III) oxyhydroxide (FeOOH) is significantly shifted towards the higher pH values in the presence of Chit indicating that some interaction takes place between the iron(III) and the polymer. However, the additivity of the pH-metric titration curves, the lack of variation both in the viscometric and IR spectra of Chit in the presence and absence of iron(III), indicate the lack of direct complexation between the Chit and ferric ions. Isolated FeOOH nanospheres of 5-10 nm diameter were observed on the transmission electron microscopic pictures of samples obtained from solutions containing iron(III) and Chit, while from DLS measurements hydrodynamic units with a few hundred nm in diameter were identified. Our data support that Chit acts as steric stabilizer and inhibits the macroscopic aggregation of the subcolloidal FeOOH particles. Thus the iron(III)-Chit interactions offer a simple and economic way to fabricate nanometric size FeOOH spheres, morphologically similar to the core of iron(III)-storage protein, ferritin.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume95
Issue number1
DOIs
Publication statusPublished - May 1 2003

Fingerprint

Chitosan
Nanoparticles
Iron
Polymers
Nanospheres
ferrihydrite
Viscosity measurement
Dynamic light scattering
Hydrodynamics
Ferritins
Complexation
Titration
Electron microscopy
Infrared spectroscopy
Spectrum Analysis
Electron Microscopy
Agglomeration
Economics
Electrons
Ions

Keywords

  • Chitosan
  • Dynamic light scattering
  • Electron microscopy
  • Ferritin
  • IR spectroscopy
  • Iron(III)
  • Nanostructure
  • pH-potentiometry
  • Polysaccharides
  • Viscometry

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Formation of spherical iron(III) oxyhydroxide nanoparticles sterically stabilized by chitosan in aqueous solutions. / Sipos, P.; Berkesi, O.; Tombácz, E.; St. Pierre, Tim G.; Webb, John.

In: Journal of Inorganic Biochemistry, Vol. 95, No. 1, 01.05.2003, p. 55-63.

Research output: Contribution to journalArticle

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AB - The interactions between the cationic polymer chitosan (Chit) and iron(III) were investigated. The solution properties were studied by pH-metry, viscometry and dynamic light scattering. Solid state iron(III)-Chit samples were also prepared and characterized by IR spectroscopy and electron microscopy. In aqueous solutions, the precipitation pH of the iron(III) oxyhydroxide (FeOOH) is significantly shifted towards the higher pH values in the presence of Chit indicating that some interaction takes place between the iron(III) and the polymer. However, the additivity of the pH-metric titration curves, the lack of variation both in the viscometric and IR spectra of Chit in the presence and absence of iron(III), indicate the lack of direct complexation between the Chit and ferric ions. Isolated FeOOH nanospheres of 5-10 nm diameter were observed on the transmission electron microscopic pictures of samples obtained from solutions containing iron(III) and Chit, while from DLS measurements hydrodynamic units with a few hundred nm in diameter were identified. Our data support that Chit acts as steric stabilizer and inhibits the macroscopic aggregation of the subcolloidal FeOOH particles. Thus the iron(III)-Chit interactions offer a simple and economic way to fabricate nanometric size FeOOH spheres, morphologically similar to the core of iron(III)-storage protein, ferritin.

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