Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells

E. Tyihák, J. Bocsi, F. Timár, G. Rácz, B. Szende

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Formaldehyde was applied in various doses (0.1-10.0 mM) to HT-29 human colon carcinoma and HUV-EC-C human endothelial cell cultures. Cell number, apoptotic and mitotic index as well as proportion of cells in S-phase was investigated by morphological methods and flow cytometry. Ten mM of formaldehyde caused high degree of cell damage and practically eradicated the cell cultures. One mM of formaldehyde enhanced apoptosis and reduced mitosis in both types of cell cultures, in a moderate manner. The low dose (0.1 mM) enhanced cell proliferation and decreased apoptotic activity of the cultured cells, the tumour cells appeared to be more sensitive. The possible role of this dose-dependent effect of formaldehyde in various pathological conditions, such as carcinogenesis and atherogenesis is discussed with emphasis on the eventual interaction between formaldehyde and hydrogen peroxide.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalCell Proliferation
Volume34
Issue number3
DOIs
Publication statusPublished - 2001

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Cultured Tumor Cells
Formaldehyde
Endothelial Cells
Cell Culture Techniques
Mitotic Index
S Phase
Mitosis
Hydrogen Peroxide
Atherosclerosis
Flow Cytometry
Colon
Carcinogenesis
Cell Count
Cell Proliferation
Apoptosis
Carcinoma

ASJC Scopus subject areas

  • Cell Biology

Cite this

Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells. / Tyihák, E.; Bocsi, J.; Timár, F.; Rácz, G.; Szende, B.

In: Cell Proliferation, Vol. 34, No. 3, 2001, p. 135-141.

Research output: Contribution to journalArticle

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