Formaldehyde generators and capturers as influencing factors of mitotic and apoptotic processes

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Abstract

There is a growing amount of evidence pointing to the fact that several endogenous and exogenous methylated compounds are potential formaldehyde generators in their biological reactions. N(ε)-methylated lysines, N(G)-methylated as well as hydroxymethylated arginines, and 1'-methyl-ascorbigen have been examined in this respect. The apoptosis-inducing effect of formaldehyde molecules formed from methyl groups was earlier first published by our group. Dimedone, an artificial capturer molecule for formaldehyde, has been found to prevent the apoptosis-inducing effect of 1'-methyl-ascorbigen as well as N(G)-hydroxymethylated arginines. More recently resveratrol, present in grapes and wines, has been shown to have cardioprotective and cancer chemopreventive effect. Our group has been successful in demonstrating that this natural formaldehyde capturer molecule can also influence cell proliferation and apoptosis. The apoptosis-inducing or -preventing effect of formaldehyde generators and capturers seems to be dose-dependent and may be utilized in various disturbances of cell proliferation and active cell death.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalActa Biologica Hungarica
Volume49
Issue number2-4
Publication statusPublished - 1998

Fingerprint

formaldehyde
Formaldehyde
apoptosis
Apoptosis
Cell proliferation
Molecules
arginine
Arginine
cell proliferation
Cell Proliferation
Wine
resveratrol
Vitis
Cell death
Lysine
wines
cell death
grapes
cancer
lysine

Keywords

  • 1'-methyl-ascorbigen
  • Apoptosis
  • Cell proliferation
  • Dimedone
  • N(G)-hydroxymethylated arginines
  • Resveratrol

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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title = "Formaldehyde generators and capturers as influencing factors of mitotic and apoptotic processes",
abstract = "There is a growing amount of evidence pointing to the fact that several endogenous and exogenous methylated compounds are potential formaldehyde generators in their biological reactions. N(ε)-methylated lysines, N(G)-methylated as well as hydroxymethylated arginines, and 1'-methyl-ascorbigen have been examined in this respect. The apoptosis-inducing effect of formaldehyde molecules formed from methyl groups was earlier first published by our group. Dimedone, an artificial capturer molecule for formaldehyde, has been found to prevent the apoptosis-inducing effect of 1'-methyl-ascorbigen as well as N(G)-hydroxymethylated arginines. More recently resveratrol, present in grapes and wines, has been shown to have cardioprotective and cancer chemopreventive effect. Our group has been successful in demonstrating that this natural formaldehyde capturer molecule can also influence cell proliferation and apoptosis. The apoptosis-inducing or -preventing effect of formaldehyde generators and capturers seems to be dose-dependent and may be utilized in various disturbances of cell proliferation and active cell death.",
keywords = "1'-methyl-ascorbigen, Apoptosis, Cell proliferation, Dimedone, N(G)-hydroxymethylated arginines, Resveratrol",
author = "B. Szende and E. Tyih{\'a}k and L. Tr{\'e}zl and E. Szőke and I. L{\'a}szl{\'o} and G. K{\'a}tay and Z. Kir{\'a}ly-V{\'e}ghely",
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T1 - Formaldehyde generators and capturers as influencing factors of mitotic and apoptotic processes

AU - Szende, B.

AU - Tyihák, E.

AU - Trézl, L.

AU - Szőke, E.

AU - László, I.

AU - Kátay, G.

AU - Király-Véghely, Z.

PY - 1998

Y1 - 1998

N2 - There is a growing amount of evidence pointing to the fact that several endogenous and exogenous methylated compounds are potential formaldehyde generators in their biological reactions. N(ε)-methylated lysines, N(G)-methylated as well as hydroxymethylated arginines, and 1'-methyl-ascorbigen have been examined in this respect. The apoptosis-inducing effect of formaldehyde molecules formed from methyl groups was earlier first published by our group. Dimedone, an artificial capturer molecule for formaldehyde, has been found to prevent the apoptosis-inducing effect of 1'-methyl-ascorbigen as well as N(G)-hydroxymethylated arginines. More recently resveratrol, present in grapes and wines, has been shown to have cardioprotective and cancer chemopreventive effect. Our group has been successful in demonstrating that this natural formaldehyde capturer molecule can also influence cell proliferation and apoptosis. The apoptosis-inducing or -preventing effect of formaldehyde generators and capturers seems to be dose-dependent and may be utilized in various disturbances of cell proliferation and active cell death.

AB - There is a growing amount of evidence pointing to the fact that several endogenous and exogenous methylated compounds are potential formaldehyde generators in their biological reactions. N(ε)-methylated lysines, N(G)-methylated as well as hydroxymethylated arginines, and 1'-methyl-ascorbigen have been examined in this respect. The apoptosis-inducing effect of formaldehyde molecules formed from methyl groups was earlier first published by our group. Dimedone, an artificial capturer molecule for formaldehyde, has been found to prevent the apoptosis-inducing effect of 1'-methyl-ascorbigen as well as N(G)-hydroxymethylated arginines. More recently resveratrol, present in grapes and wines, has been shown to have cardioprotective and cancer chemopreventive effect. Our group has been successful in demonstrating that this natural formaldehyde capturer molecule can also influence cell proliferation and apoptosis. The apoptosis-inducing or -preventing effect of formaldehyde generators and capturers seems to be dose-dependent and may be utilized in various disturbances of cell proliferation and active cell death.

KW - 1'-methyl-ascorbigen

KW - Apoptosis

KW - Cell proliferation

KW - Dimedone

KW - N(G)-hydroxymethylated arginines

KW - Resveratrol

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