Formaldehyde generation by N-demethylation

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Microsomal oxidation of exogenic compounds yields efferent metabolites with small molecular size. N-demethylation results in formaldehyde generation in addition to the nor-compound. Interesting changes in the level of formaldehyde elimination were observed after a single dose of either (-)-deprenyl or (+)-deprenyl. Urine elimination of the generated formaldehyde was determined using thin-layer chromatography after derivatization with dimedone.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalActa Biologica Hungarica
Volume49
Issue number2-4
Publication statusPublished - 1998

Fingerprint

formaldehyde
Formaldehyde
Selegiline
Thin layer chromatography
derivatization
Thin Layer Chromatography
Metabolites
thin layer chromatography
urine
chromatography
metabolite
Urine
oxidation
metabolites
Oxidation
dosage

Keywords

  • (-)-deprenyl
  • Efferent metabolites
  • Formaldehyde
  • In situ formaldehyde
  • In vivo formaldehyde

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Formaldehyde generation by N-demethylation. / Kalász, H.; Báthori, M.; Tyihák, E.

In: Acta Biologica Hungarica, Vol. 49, No. 2-4, 1998, p. 339-344.

Research output: Contribution to journalArticle

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