Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis

Nadezhda Bazhan, D. Zelena

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Emotional stress induces anorexia in laboratory animals, and obesity in humans.Stress per se does not result in overeating and obesity, only at high caloric diet.Glucocorticoids stimulate and stress inhibits food intake in laboratory animals.In animals the orexigenic effects of glucocorticoids are overcome by other factors (like CRH) at acute and chronic stresses. The prevalence of obesity is increasing worldwide with serious consequences such as diabetes mellitus type 2 and cardiovascular diseases. Emotional stress is considered to be one of the main reasons of obesity development in humans. However, there are some contradictory results, which should be addressed. First of all stress induces anorexia, but not overeating in laboratory animals. Glucocorticoids, the effector molecules of the hypothalamo-pituitary-adrenocortical (HPA) axis stimulate and stress inhibits food intake. It is also not clear if stress is diabetogenic or an antidiabetogenic factor. The review will discusses these issues and the involvement of the whole HPA axis and its separate molecules (glucocorticoids, adrenocorticotropin, corticotropin-releasing hormone) in food intake regulation under stress.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalBrain Research Bulletin
Volume95
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Appetite Regulation
Glucocorticoids
Laboratory Animals
Obesity
Hyperphagia
Anorexia
Psychological Stress
Eating
Corticotropin-Releasing Hormone
Human Development
Adrenocorticotropic Hormone
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Diet

Keywords

  • ACTH
  • CRH
  • Food intake regulation
  • Glucocorticoid
  • Obesity
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis. / Bazhan, Nadezhda; Zelena, D.

In: Brain Research Bulletin, Vol. 95, 06.2013, p. 46-53.

Research output: Contribution to journalArticle

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