Follow-Up of Thrombin Generation after Prostate Cancer Surgery: Global Test for Increased Hypercoagulability

Matyas Benyo, Tibor Flasko, Zsuzsanna Molnar, Adrienne Kerenyi, Zoltan Batta, Tamas Jozsa, J. Hársfalvi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these processes providing sufficient evaluation of an individual's hemostatic competence and response to anticoagulant therapy. The objective of the study is to assess a new measure of hypercoagulability that predisposes to venous thromboembolism in the postoperative period after radical prostatectomy. Pre- (day-1) and postoperative (hour 1, day 6, month 1 and 10) blood samples of 24 patients were tested for plasma thrombin generation (peak thrombin), routine hematology and hemostasis. Patients received low molecular weight heparin for thromboprophylaxis. Peak thrombin levels were higher in patients compared to controls at baseline (p

Original languageEnglish
Article numbere51299
JournalPLoS One
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 7 2012

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Thrombophilia
thrombin
prostatic neoplasms
Thrombin
Surgery
Prostatic Neoplasms
surgery
testing
hemostasis
anticoagulants
Low Molecular Weight Heparin
Venous Thromboembolism
heparin
Hematology
Hemostatics
hematology
Prostatectomy
Hemostasis
Postoperative Period
blood vessels

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Follow-Up of Thrombin Generation after Prostate Cancer Surgery : Global Test for Increased Hypercoagulability. / Benyo, Matyas; Flasko, Tibor; Molnar, Zsuzsanna; Kerenyi, Adrienne; Batta, Zoltan; Jozsa, Tamas; Hársfalvi, J.

In: PLoS One, Vol. 7, No. 12, e51299, 07.12.2012.

Research output: Contribution to journalArticle

Benyo, Matyas ; Flasko, Tibor ; Molnar, Zsuzsanna ; Kerenyi, Adrienne ; Batta, Zoltan ; Jozsa, Tamas ; Hársfalvi, J. / Follow-Up of Thrombin Generation after Prostate Cancer Surgery : Global Test for Increased Hypercoagulability. In: PLoS One. 2012 ; Vol. 7, No. 12.
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