Follow-up of prostate carcinoma patients treated with total androgen blockade by repeated map-biopsy

J. Szabo, K. Bartok, T. Kereni, A. Vegh, I. Romics, B. Szende

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

A prospective study was carried out on ten patients with prostate cancer. The TNM stage, Gleason's grade, general clinical status and, serum PSA level were all registered by the time of diagnosis. Total androgen blockade (TAB) was performed. Serum PSA control and general clinical examination re-biopsy was performed on average 107 days after the start of the therapy. The pre- and post treatment histology included HE and Tunel reaction to show apoptotic cells, as well as p53, bcl2 and Ki67 immunostaining. Clinical improvement of the disease, manifested by regression or by steady state was observed in all ten patients. An increase of apoptotic index, and a decrease of mitotic index was detected in most cases. The serum PSA level decreased in all patients. Ki67, bcl2 and mutant p53 were strongly expressed in tumor cells of patients in whom Gleason's grade was 7 or higher and decreased markedly in all cases upon therapy. Data obtained by repeated biopsy in the course of TAB therapy are indicators of the effectiveness of TAB, like changes in serum PSA, and may be considered as predictive factors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalAnnales d'Urologie
Volume34
Issue number4
Publication statusPublished - Sep 14 2000

Keywords

  • Biopsy map
  • Prostate cancer
  • Total androgen blockade

ASJC Scopus subject areas

  • Urology

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