Folded-unfolded cross-predictions and protein evolution: The case study of coiled-coils

Balázs Szappanos, Dániel Süveges, László Nyitray, András Perczel, Zoltán Gáspári

Research output: Contribution to journalArticle

16 Citations (Scopus)


Here we report a thorough analysis of cross-predictions between coiled-coil and disordered protein segments using various prediction algorithms for both sequence classes. Coiled-coils are often predicted to be unstructured, consistent with their obligate multimeric nature, whereas reverse cross-predictions are rare due to the regularity of coiled-coil sequences. We propose the simultaneous use of the programs C. oils and IUP. red to achieve acceptable prediction accuracy and minimize the extent of cross-predictions. The relevance of observed cross-predictions might be that disordered sequences can adopt coiled-coil conformation relatively easily during protein evolution.

Original languageEnglish
Pages (from-to)1623-1627
Number of pages5
JournalFEBS letters
Issue number8
Publication statusPublished - Apr 1 2010



  • Coiled-coil
  • Intrinsically disordered protein
  • Protein evolution
  • Structure prediction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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